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Teprotide is a nine-residue peptide inhibitor of angiotensin-converting enzyme (ACE) originally identified through research on bradykinin-potentiating peptides from Bothrops jararaca venom.
Also known as BPP-9a or SQ 20,881, Teprotide occupies an important position in the history of ACE inhibitor pharmacology and remains a useful reference peptide for studying metallopeptidase inhibition and peptide structure–activity relationships.
Product Information
| Property | Specification |
|---|---|
| Product Name | Teprotide |
| CAS No. | 35115-60-7 |
| Sequence | pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro |
| Peptide Length | 9 amino-acid residues |
| Molecular Formula | C53H76N14O12 |
| Molecular Weight | Approximately 1101.3 Da |
| N-Terminus | Pyroglutamate |
| Primary Target | Angiotensin-converting enzyme / kininase II |
| Synonyms | BPP-9a, SQ 20,881 |
Peptide ACE Inhibition
ACE is a zinc metallopeptidase that participates in both Angiotensin I conversion and bradykinin degradation. Teprotide inhibits this enzyme and therefore provides a peptide-based tool for examining both catalytic functions.
Its proline-rich sequence and N-terminal pyroglutamate distinguish it structurally from short ACE substrates and from later small-molecule ACE inhibitors.
A Landmark Peptide in ACE Inhibitor Design
Teprotide was one of the early peptide inhibitors used to demonstrate that pharmacological blockade of ACE could produce substantial biological effects.
Structure–activity work on Teprotide and related venom-derived peptides contributed to models of the ACE active site that subsequently informed development of non-peptide inhibitors.
We consider Teprotide particularly useful as a research scaffold when comparing peptide-based enzyme recognition with small-molecule metalloprotease inhibition.
Experimental Considerations
Measured inhibition depends on ACE source, substrate identity, chloride concentration, metal-ion environment and assay format. IC50 values obtained with different substrates should therefore not be treated as directly interchangeable.
Peptide identity and chromatographic purity can be evaluated through our Peptide Quality Control capabilities.
Frequently Asked Questions
Is Teprotide an ACE substrate?
No. Teprotide is a peptide inhibitor of ACE/kininase II.
Why is Teprotide important in peptide pharmacology?
Studies of Teprotide and related venom peptides helped establish ACE as a pharmacologically tractable target and informed later inhibitor design.