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Human Angiotensin I is a 10-amino-acid peptide intermediate in the renin–angiotensin system. It is generated from angiotensinogen by renin and serves as the principal precursor of Angiotensin II in the classical RAS pathway.
The sequence contains a C-terminal His-Leu dipeptide that is removed by angiotensin-converting enzyme (ACE), generating the eight-residue Angiotensin II molecule.
Product Information
| Property | Specification |
|---|---|
| Product Name | Angiotensin I, Human |
| CAS No. | 484-42-4 |
| Sequence | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu |
| One-Letter Sequence | DRVYIHPFHL |
| Peptide Length | 10 amino acids |
| Molecular Formula | C62H89N17O14 |
| Molecular Weight | Approximately 1296.48 Da |
| Primary Processing Enzyme | Angiotensin-converting enzyme (ACE) |
| Research Areas | RAS processing, ACE activity, cardiovascular and renal biology |
| Purity | Crude to 98% |
Conversion of Angiotensin I to Angiotensin II
ACE removes the C-terminal His-Leu dipeptide from Angiotensin I:
DRVYIHPFHL → DRVYIHPF
The resulting octapeptide is Angiotensin II, an important signaling ligand within the classical RAS.
This defined precursor–product relationship makes Angiotensin I useful for studying ACE catalytic activity and the generation of downstream vasoactive peptides.
ACE-Independent Processing
Angiotensin I can also be processed through alternative enzymatic pathways. Human chymase, for example, can generate Angiotensin II through cleavage of the Phe8–His9 bond.
We consider enzyme identity important when Angiotensin II formation is measured in complex tissues because product generation does not automatically establish ACE as the only contributing protease.
Research Applications
Human Angiotensin I can support ACE assays, RAS pathway studies, peptide-processing experiments and comparative analysis of Angiotensin I, Angiotensin II and downstream metabolites.
Related RAS reagents are available in our Cardiovascular Peptides collection.
Experimental Considerations
Peptidase contamination can alter Angiotensin I during extended incubations. Sample preparation, incubation time and protease composition should therefore be controlled when conversion products are quantified.
Our Peptide Quality Control capabilities support analytical HPLC and mass-spectrometric confirmation according to the selected specification.
Frequently Asked Questions
How many amino acids are in human Angiotensin I?
Human Angiotensin I contains 10 amino-acid residues.
How does ACE convert Angiotensin I to Angiotensin II?
ACE removes the C-terminal His-Leu dipeptide, converting the 10-residue precursor into the eight-residue Angiotensin II peptide.
Can modified Angiotensin I sequences be prepared?
Species variants, labeled peptides and defined sequence modifications can be evaluated through Chemical Peptide Synthesis.