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[Val5]-Angiotensin II is an eight-residue Angiotensin II analog in which Ile5 is replaced by valine. Its sequence, Asp-Arg-Val-Tyr-Val-His-Pro-Phe (DRVYVHPF), differs from human Angiotensin II by a single conservative residue substitution.
The analog retains angiotensin receptor agonist activity and has been used extensively in experimental studies of receptor-mediated peptide uptake and intrarenal Angiotensin II handling.
Product Information
| Property | Specification |
|---|---|
| Product Name | [Val5]-Angiotensin II |
| CAS No. | 58-49-1 |
| Sequence | Asp-Arg-Val-Tyr-Val-His-Pro-Phe |
| One-Letter Sequence | DRVYVHPF |
| Peptide Length | 8 amino acids |
| Molecular Formula | C49H69N13O12 |
| Molecular Weight | Approximately 1032.2 Da |
| Key Substitution | Ile5 → Val |
| Research Areas | Angiotensin receptors, renal uptake, peptide metabolism, RAS pharmacology |
A Single-Residue Angiotensin II Analog
Human Angiotensin II contains Ile at position 5:
DRVYIHPF
[Val5]-Angiotensin II contains Val at the same position:
DRVYVHPF
The conservative Ile-to-Val substitution preserves the overall Angiotensin II scaffold while producing a chemically distinguishable analog.
Use in Renal Uptake Studies
[Val5]-Angiotensin II has been used as an experimental tracer and receptor ligand in studies of renal and adrenal Angiotensin II uptake.
Radiolabeled [Val5]-Angiotensin II studies demonstrated strong AT1 receptor dependence of intracellular peptide uptake in kidney and adrenal tissue.
We consider this a particularly useful application of the analog: the sequence difference provides an experimental handle while retaining Angiotensin II-like receptor pharmacology.
Experimental Considerations
The Val5 analog should not be reported as chemically identical to human Ile5-Angiotensin II. Chromatographic and mass-spectrometric methods can exploit the sequence difference when exogenous and endogenous peptides need to be distinguished.
Related angiotensin analogs can be evaluated through our Chemical Peptide Synthesis capabilities.
Frequently Asked Questions
How does [Val5]-Angiotensin II differ from human Angiotensin II?
Valine replaces isoleucine at residue 5. The remaining seven residues are unchanged.
Is CAS 58-49-1 an acetate salt of normal human Angiotensin II?
No. CAS 58-49-1 identifies the Val5-Angiotensin II sequence DRVYVHPF.