$181.00 - $181.00
Ac-Angiotensinogen (1-14), human is an N-terminally acetylated 14-residue peptide derived from the human angiotensinogen sequence. It contains the renin cleavage region and provides a chemically defined substrate for studies of renin activity and substrate recognition.
Product Information
| Property | Specification |
|---|---|
| Product Name | Ac-Angiotensinogen (1-14), Human |
| CAS No. | 104180-27-0 |
| Sequence | Ac-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn |
| One-Letter Sequence | Ac-DRVYIHPFHLVIHN |
| Peptide Length | 14 amino-acid residues |
| Molecular Formula | C85H124N24O20 |
| Molecular Weight | Approximately 1802.04 Da |
| N-Terminus | Acetylated |
| Primary Research Enzyme | Renin |
Human Renin Cleavage-Site Context
The sequence spans the human angiotensinogen N-terminal region surrounding the physiologically relevant renin cleavage site.
Renin cleaves between Leu10 and Val11. In this synthetic N-acetylated substrate, cleavage therefore produces an acetylated Angiotensin I-derived N-terminal fragment together with the downstream VIHN fragment.
This distinction matters when cleavage products are analyzed by mass spectrometry or chromatography because the synthetic substrate does not generate chemically unmodified Angiotensin I.
Why Use a 14-Residue Renin Substrate?
The additional residues beyond Angiotensin I provide local sequence context around the scissile bond while remaining substantially smaller and easier to characterize than full-length angiotensinogen.
It can therefore support enzyme kinetic studies, inhibitor screening and experiments examining how sequence context influences renin recognition.
Experimental Planning
Human and porcine angiotensinogen substrates should not be treated as interchangeable in kinetic comparisons. Species sequence and terminal chemistry should be recorded together with enzyme source and reaction conditions.
We recommend confirming molecular identity and purity through our Peptide Quality Control capabilities when quantitative cleavage measurements are planned.
Frequently Asked Questions
Is Ac-Angiotensinogen (1-14) full-length angiotensinogen?
No. It is a synthetic 14-residue N-terminal fragment.
What enzyme is this peptide designed to study?
It is commonly used as a defined substrate for renin.
Can species-specific renin substrates be prepared?
Human, porcine and other defined sequences can be evaluated through Chemical Peptide Synthesis.