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Rat Gastrin I is a 17-amino-acid amidated gastrin peptide used in CCK2R signaling and gastrointestinal studies in rodent systems.
Its molecular architecture includes an N-terminal pyroglutamate, an acidic central region and the conserved amidated C-terminal gastrin motif.
Product Information
| Property | Specification |
|---|---|
| Product Name | Gastrin I, Rat |
| Catalog No. | AS2675 |
| CAS No. | 81123-06-0 |
| Sequence | pGlu-Arg-Pro-Pro-Met-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH₂ |
| Peptide Length | 17 amino acids |
| Molecular Weight | Approximately 2126.3 Da |
| C-Terminus | Amide |
| Primary Target | CCK2R / CCKBR |
| Purity | Crude to 98% |
Species-Matched Gastrin Research
Rat and human Gastrin-17 share the conserved C-terminal Trp-Met-Asp-Phe-NH₂ region while differing at several upstream residues.
Species-matched material can be useful when the experimental objective is to reproduce endogenous ligand biology in rodent models.
Experimental Considerations
Terminal structure and peptide identity remain central specifications for receptor assays. Purity should be selected according to the sensitivity of the downstream experiment.
Researchers can review our Recommended Peptide Purity guidance when planning a study.
Frequently Asked Questions
What region of rat Gastrin I is closely associated with CCK2R activation?
The amidated C-terminal gastrin motif is a major determinant of receptor recognition.
Can additional rat gastrin variants be synthesized?
Sequence variants and labeled constructs can be evaluated through Chemical Peptide Synthesis.