$151.00 - $151.00
Biotin-Gastrin (1-17) is a biotinylated gastrin construct containing the complete 17-residue gastrin sequence with an N-terminal biotin modification.
The listed structure begins with Biotin-Glu, which differs from the N-terminal pyroglutamate found in mature human Gastrin-17. The amidated C-terminal gastrin sequence is retained.
Product Information
| Property | Specification |
|---|---|
| Product Name | Biotin-Gastrin (1-17) |
| Catalog No. | AS2627 |
| Sequence | Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH₂ |
| Peptide Length | 17 amino acids |
| Molecular Weight | Approximately 2342.5 Da |
| Modification | N-terminal biotin |
| C-Terminus | Amide |
| Research Areas | Gastrin binding, affinity assays, receptor interaction |
| Purity | Crude to 98% |
Molecular Design
The C-terminal gastrin region remains intact, including the amidated Trp-Met-Asp-Phe-NH₂ motif associated with CCK2R recognition.
N-terminal biotinylation changes the chemical structure at the opposite end of the molecule. Biotin-Gastrin should therefore be treated as a defined labeled analog rather than as chemically identical to native Gastrin-17.
We consider label position particularly relevant when receptor affinity or signaling is measured quantitatively.
Research Applications
Biotin-Gastrin (1-17) can support streptavidin-based capture, ligand-binding studies, peptide detection and receptor-oriented interaction assays.
Researchers working with native and modified gastrin ligands can explore the Gastrin, GRP & Bombesin Peptides collection.
Experimental Considerations
For quantitative receptor studies, the labeled peptide should be compared with an appropriate unlabeled control when possible. Purity, terminal chemistry and molecular mass should also be confirmed according to the downstream assay.
Alternative spacer lengths, labeling positions and related conjugates can be evaluated through Chemical Peptide Synthesis.
Frequently Asked Questions
Is Biotin-Gastrin (1-17) identical to native Gastrin-17?
No. The N-terminal biotin modification changes the molecular structure, while the C-terminal gastrin sequence remains intact.
Why does the position of biotin matter?
Label placement can affect steric environment, physicochemical behavior and receptor interaction. It should therefore be considered when comparing labeled and unlabeled peptides.