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Gastrin I (1-14), human is a defined N-terminal fragment of Gastrin-17 containing residues 1 through 14.
The peptide terminates at Trp14 and therefore lacks the native Met-Asp-Phe-NH₂ segment found at the C-terminus of mature Gastrin-17.
Product Information
| Property | Specification |
|---|---|
| Product Name | Gastrin I (1-14), Human |
| CAS No. | 100940-57-6 |
| Sequence | pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp |
| Peptide Length | 14 amino acids |
| Molecular Weight | Approximately 1705.7 Da |
| N-Terminus | Pyroglutamate |
| C-Terminus | Free carboxyl terminus |
| Research Areas | Gastrin processing, peptide fragments, sequence-function studies |
| Purity | Crude to 98% |
Fragment Design
Removal of residues 15–17 substantially changes the C-terminal molecular structure associated with classical gastrin receptor activation.
Gastrin I (1-14) is therefore suited to studies of peptide processing, fragment biology and sequence-dependent effects rather than direct substitution for mature Gastrin-17.
We consider this distinction important when selecting research material because peptides carrying the same gastrin family name can represent different experimental tools.
Experimental Planning
Researchers comparing full-length and truncated gastrins should match assay conditions and purity while accounting for their different terminal structures.
Additional gastrin-family materials are available in the Gastrin, GRP & Bombesin Peptides collection.
Frequently Asked Questions
Is Gastrin I (1-14) equivalent to Gastrin-17?
No. It lacks the final three residues and the mature C-terminal amide.
Can additional gastrin fragments be prepared?
Defined truncations can be evaluated through Chemical Peptide Synthesis.