$151.00 - $151.00
Big Gastrin-1, human, commonly referred to as Gastrin-34, is a 34-amino-acid gastrin molecular form containing an extended N-terminal region together with the conserved C-terminal sequence associated with CCK2 receptor recognition.
Its longer sequence makes it useful for studies of gastrin processing, molecular-form-dependent biology and comparison with shorter Gastrin-17.
Product Information
| Property | Specification |
|---|---|
| Product Name | Big Gastrin-1, Human |
| Catalog No. | AS2619 |
| Sequence | pGlu-Leu-Gly-Pro-Gln-Gly-Pro-Pro-His-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH₂ |
| Peptide Length | 34 amino acids |
| Molecular Weight | Approximately 3849.3 Da |
| N-Terminus | Pyroglutamate |
| C-Terminus | Amide |
| Primary Target | CCK2R / CCKBR |
| Purity | Crude to 98% |
| Research Areas | Gastrin processing, CCK2R signaling, peptide molecular-form studies |
Gastrin-34 Molecular Form
Big Gastrin-1 contains a longer N-terminal sequence than Gastrin-17 while preserving the characteristic C-terminal gastrin region.
This allows researchers to compare two related mature gastrin forms without altering the principal C-terminal receptor-recognition motif.
The extended sequence also changes molecular mass, charge distribution and chromatographic behavior, which can influence experimental handling and analytical separation.
Research Applications
Human Gastrin-34 can be used in studies of gastrin biosynthesis and processing, CCK2R signaling, gastrointestinal endocrine biology and comparison of circulating gastrin molecular forms.
Related gastrin, GRP and Bombesin ligands are available in the Gastrin, GRP & Bombesin Peptides collection.
Synthetic and Quality Considerations
Gastrin-34 is longer and more acidic than many short receptor ligands. Sequence identity, terminal structure, molecular mass and chromatographic purity should be considered together when selecting material for quantitative studies.
Researchers can review our Recommended Peptide Purity guidance when planning the required specification.
Frequently Asked Questions
Is Big Gastrin the same as Gastrin-17?
No. Big Gastrin contains 34 amino-acid residues, while Gastrin-17 contains 17. They retain a related C-terminal receptor-active region.
Can Gastrin-34 fragments or labeled variants be prepared?
Defined fragments, labels and sequence modifications can be evaluated through Chemical Peptide Synthesis.