$302.00 - $302.00
Rat α-CGRP is a 37-residue endogenous calcitonin gene-related peptide with the sequence SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH₂. The mature peptide contains a Cys2-Cys7 disulfide bond and an amidated C-terminal phenylalanine, both of which are part of its native molecular architecture.
As the full-length rat α-CGRP isoform, this peptide is widely used in receptor pharmacology, vascular signaling, sensory-neuropeptide studies and comparative analysis of CGRP-family ligands.
Product Information
| Property | Specification |
|---|---|
| Product Name | Rat α-CGRP |
| CAS No. | 96827-03-1 |
| Synonyms | Rat CGRP-I; Rat α-Calcitonin Gene-Related Peptide |
| Sequence | Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH₂ |
| One-Letter Sequence | SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH₂ |
| Peptide Length | 37 amino-acid residues |
| Molecular Formula | C162H262N50O52S2 |
| Molecular Weight | Approximately 3806.25 Da |
| Disulfide Bond | Cys2-Cys7 |
| C-Terminus | Phe-NH₂ |
| Gene / Precursor | Calca / preprocalcitonin |
| Primary Receptor System | CLR–RAMP1 CGRP receptor |
Native Rat α-CGRP Architecture
The N-terminal portion of α-CGRP contains a disulfide bridge between Cys2 and Cys7, forming a constrained ring that contributes to receptor activation. The C-terminal region remains amidated and provides an important recognition surface for receptor binding.
These two regions perform different structural roles. The N-terminus is strongly associated with agonist activation, while the C-terminal segment contributes substantially to ligand recognition. This division is particularly useful when full-length α-CGRP is compared with truncated antagonists such as CGRP (8-37).
CLR–RAMP1 Receptor Signaling
The canonical CGRP receptor is formed by the calcitonin receptor-like receptor (CLR, encoded by Calcrl) together with receptor activity-modifying protein 1 (RAMP1). RAMP1 contributes directly to the ligand-recognition properties of the receptor complex.
Activation of this receptor commonly stimulates Gs-dependent cAMP signaling, although the measured response can vary with receptor expression level, accessory proteins and cellular background.
We recommend reporting both CLR and RAMP1 expression when recombinant CGRP receptor systems are used because CLR alone does not define a complete functional CGRP receptor phenotype.
Full-Length Agonist Versus CGRP (8-37)
Rat α-CGRP and rat CGRP (8-37) are closely related experimentally but serve different purposes.
| Feature | Rat α-CGRP | Rat CGRP (8-37) |
|---|---|---|
| Length | 37 residues | 30 residues |
| N-Terminal Ring | Present | Absent |
| Disulfide Bond | Cys2-Cys7 | None |
| Typical Research Role | Agonist | Antagonist |
This paired-ligand design is useful for determining whether a measured response depends on CGRP receptor activation rather than nonspecific peptide exposure.
The corresponding antagonist fragment is available as Rat CGRP (8-37).
Rat α-CGRP and β-CGRP
Rat α-CGRP should also be distinguished from rat β-CGRP (CGRP II). The two isoforms share the same overall 37-residue architecture but contain defined sequence differences and arise from different genetic contexts.
For isoform-comparison studies, exact sequence identity is important because small substitutions can influence receptor potency, tissue responses or peptide stability.
Related isoforms and truncated ligands can be explored in our Calcitonin & CGRP Family Peptides collection.
Research Applications
Rat α-CGRP can support CGRP receptor signaling studies, cAMP assays, vascular and smooth-muscle research, sensory-neuropeptide experiments, ligand competition and comparative α-/β-CGRP pharmacology.
It can also serve as a native full-length reference when evaluating N-terminal truncations, residue substitutions or labeled CGRP analogs.
Experimental and Quality Considerations
Quantitative receptor experiments should account for peptide oxidation state, C-terminal amidation and concentration accuracy. The intended molecular form contains the Cys2-Cys7 disulfide bridge; a reduced peptide should not be treated as equivalent to mature α-CGRP.
For receptor-binding or cellular studies, our Peptide Quality Control capabilities support analytical HPLC and mass spectrometry according to the selected specification.
Frequently Asked Questions
Is rat CGRP the same as rat α-CGRP?
For CAS 96827-03-1 and the sequence SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH₂, the product is rat α-CGRP, also called rat CGRP-I.
Does rat α-CGRP contain a disulfide bond?
Yes. Cys2 and Cys7 form the characteristic N-terminal disulfide bridge.
What is the difference between rat α-CGRP and CGRP (8-37)?
Full-length α-CGRP contains 37 residues and functions as an agonist. CGRP (8-37) lacks residues 1-7 and the N-terminal disulfide ring and is commonly used as an antagonist.
Can labeled rat CGRP analogs be synthesized?
Biotinylated, fluorescent, truncated and sequence-modified CGRP analogs can be evaluated through Chemical Peptide Synthesis.