$543.00 - $543.00
Rat α-CGRP (8-37) is a 30-residue N-terminally truncated CGRP peptide antagonist. It retains the C-terminal receptor-recognition region of rat α-CGRP while removing residues 1-7, including the disulfide-bonded N-terminal ring required for full agonist activation.
This structural separation makes CGRP (8-37) a classic pharmacological tool for distinguishing CGRP receptor-dependent responses from nonspecific peptide effects.
Product Information
| Property | Specification |
|---|---|
| Product Name | Rat α-CGRP (8-37) |
| Catalog No. | AS2646 |
| CAS No. | 129121-73-9 |
| Sequence | Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH₂ |
| One-Letter Sequence | VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH₂ |
| Peptide Length | 30 amino-acid residues |
| Molecular Formula | C138H224N42O41 |
| Molecular Weight | Approximately 3127.5 Da |
| Disulfide Bond | None |
| Pharmacological Role | CGRP receptor antagonist |
Loss of the N-Terminal Activation Domain
Full-length CGRP contains a Cys2-Cys7 ring that contributes to receptor activation. CGRP (8-37) begins immediately after that region and therefore lacks both cysteine residues.
The fragment can still recognize the receptor through its C-terminal sequence but has greatly reduced agonist activity, producing competitive antagonist behavior in established systems.
Use as a Pharmacological Control
Rat CGRP (8-37) is useful for testing whether a biological response depends on CGRP receptor activation. It can be paired with full-length rat α-CGRP in vascular, neural or recombinant receptor experiments.
We recommend optimizing antagonist concentration for the specific system instead of treating one historical concentration as universally applicable.
Frequently Asked Questions
Does rat CGRP (8-37) contain a disulfide bond?
No. Residues 1-7, including both cysteines of the native ring, are absent.
Is it an agonist or antagonist?
It is widely used as a peptide antagonist at CGRP receptor systems.