$543.00 - $543.00
GLP-1 (7-36)-Lys(Biotinyl) amide is a biotin-tagged derivative of bioactive GLP-1 (7-36) amide. An additional C-terminal Lys carrying biotin provides an affinity handle while preserving the native GLP-1 sequence through Arg36.
The construct is suited to streptavidin-based capture, receptor-interaction studies and development of affinity-oriented GLP-1 assays.
Product Information
| Property | Specification |
|---|---|
| Product Name | GLP-1 (7-36)-Lys(Biotinyl) Amide |
| Sequence | His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Lys(Biotin)-NH₂ |
| Peptide Length | 31 amino-acid residues including added Lys |
| Molecular Formula | C165H252N44O48S |
| Molecular Weight | Approximately 3652.2 Da |
| Modification | C-terminal Lys side-chain biotinylation |
| Research Target | GLP-1 receptor |
Biotin Positioned Away from the Native N-Terminus
GLP-1 receptor activation is highly sensitive to the N-terminal His7-Ala8 region. In this construct, the biotin label is introduced through an added C-terminal Lys rather than directly modifying the N-terminal activation sequence.
This architecture can be advantageous for affinity-based assays where preservation of the native N-terminal region is desirable.
Affinity and Surface-Based Applications
The biotin handle can support streptavidin capture, ligand immobilization, receptor-binding studies and analytical detection workflows.
Surface attachment can still alter peptide orientation and apparent affinity, so soluble native GLP-1 should remain an appropriate reference when quantitative receptor pharmacology is evaluated.
Quality Considerations
Mass spectrometry is useful for confirming both peptide identity and successful biotin incorporation. Our Peptide Quality Control capabilities support batch-specific analytical characterization.
Frequently Asked Questions
Is biotin attached directly to the N-terminus?
No. The listed sequence uses an additional C-terminal Lys(Biotinyl) residue.
What is the reported molecular weight?
Approximately 3652.2 Da.