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Exendin-4 (1-8) is an eight-residue N-terminal fragment of Exendin-4 with the sequence His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-NH₂.
The fragment isolates the portion of the parent ligand most closely associated with engagement of the GLP-1 receptor transmembrane activation pocket, making it useful for mechanistic sequence–activity studies rather than as a substitute for full-length Exendin-4.
Product Information
| Property | Specification |
|---|---|
| Product Name | Exendin-4 (1-8) |
| Catalog No. | AS2671 |
| CAS No. | 1802078-29-0 |
| Sequence | His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-NH₂ |
| One-Letter Sequence | HGEGTFTS-NH₂ |
| Peptide Length | 8 amino-acid residues |
| Molecular Formula | C35H51N11O13 |
| Molecular Weight | Approximately 833.86 Da |
| Research Focus | GLP-1R activation-domain and N-terminal SAR |
The Activation-Facing End of Exendin-4
Class B1 GPCR ligands often follow a two-domain recognition model: the peptide C-terminal region contributes strongly to receptor extracellular-domain binding, while the N-terminal region penetrates the transmembrane core and promotes activation.
Exendin-4 (1-8) isolates this activation-facing segment but lacks the remainder of the scaffold needed for the high-affinity pharmacology of intact Exendin-4.
Research Applications
The fragment can support minimal-sequence studies, receptor-mutagenesis experiments, conformational research and design of Exendin-derived analogs.
We recommend avoiding descriptions of the isolated octapeptide as pharmacologically equivalent to native Exendin-4, since removal of the C-terminal binding domain substantially changes receptor interaction.
Frequently Asked Questions
Does Exendin-4 (1-8) contain the entire GLP-1R-binding surface?
No. It contains only the N-terminal activation-associated portion of the parent peptide.
Is the fragment C-terminally amidated?
Yes. The listed sequence terminates in Ser-NH₂.