$121.00 - $121.00
Rat Calcitonin C-Terminal Adjacent Peptide is a 16-residue peptide associated with the calcitonin precursor. Its sequence, Asp-Met-Ala-Lys-Asp-Leu-Glu-Thr-Asn-His-His-Pro-Tyr-Phe-Gly-Asn (DMAKDLETNHHPYFGN), is chemically and structurally distinct from mature rat calcitonin.
This defined fragment is suited to studies of precursor organization, peptide processing, sequence-specific recognition and comparative analysis of calcitonin-associated peptides.
Product Information
| Property | Specification |
|---|---|
| Product Name | Calcitonin C-Terminal Adjacent Peptide, Rat |
| Catalog No. | AS2644 |
| Sequence | Asp-Met-Ala-Lys-Asp-Leu-Glu-Thr-Asn-His-His-Pro-Tyr-Phe-Gly-Asn |
| One-Letter Sequence | DMAKDLETNHHPYFGN |
| Peptide Length | 16 amino-acid residues |
| Molecular Formula | C82H117N23O27S |
| Molecular Weight | Approximately 1889.05 Da |
| C-Terminus | Free carboxyl terminus |
| Disulfide Bond | None |
| Research Context | Calcitonin precursor processing and peptide sequence analysis |
Distinct from Mature Rat Calcitonin
Mature calcitonin contains 32 residues, an N-terminal Cys1-Cys7 disulfide ring and an amidated C-terminus. Rat Calcitonin C-Terminal Adjacent Peptide lacks these defining structural features.
Its identity should therefore remain separate from mature rat calcitonin in receptor pharmacology, molecular-weight calculations and analytical interpretation.
We recommend using the exact sequence DMAKDLETNHHPYFGN when reporting the material because the term “C-terminal adjacent peptide” describes its relationship to the precursor and does not imply that it is the C-terminal portion of mature calcitonin.
Precursor-Processing Research
Peptide hormone precursors can contain multiple regions that are separated during post-translational processing. Defined adjacent fragments allow researchers to examine those regions independently from the mature hormone.
This peptide can support precursor mapping, analytical method development, sequence-specific antibody studies and comparative investigations of calcitonin precursor-derived fragments across species.
Analytical Considerations
The sequence contains a single methionine residue, making oxidation state a relevant consideration during storage and LC-MS analysis. Because the molecule has no disulfide bond, oxidative folding is not part of its intended structural identity.
Our Peptide Quality Control capabilities support chromatographic and mass-spectrometric characterization according to the selected specification.
Frequently Asked Questions
Is this peptide the C-terminal portion of mature rat calcitonin?
No. It is an adjacent precursor-derived peptide and has a different sequence and molecular architecture from mature rat calcitonin.
Does it contain the Cys1-Cys7 calcitonin disulfide bond?
No. The 16-residue sequence contains no cysteine residues.
Can related precursor fragments be synthesized?
Defined precursor sequences, truncations and labeled fragments can be evaluated through Chemical Peptide Synthesis.