$102.00 - $523.00
H-D-Arg(NO2)-OH is Nω-nitro-D-arginine, a D-arginine analog in which the guanidino group carries a nitro substituent. The compound combines defined D stereochemistry with a chemically modified guanidino functionality.
Nitroarginine chemistry appears in nitric-oxide synthase (NOS) research, where stereochemistry is important for interpreting enzyme recognition. The D analog should therefore be treated as its own entity rather than inferred to have the same activity profile as Nω-nitro-L-arginine.
Product Information
| Product Name | H-D-Arg(NO2)-OH |
| Chemical Name | Nω-Nitro-D-arginine |
| Catalog No. | AS2015 |
| CAS No. | 66036-77-9 |
| Molecular Formula | C6H13N5O4 |
| Molecular Weight | 219.20 g/mol |
| Compound Type | Nitroguanidino D-arginine analog |
| Primary Research Use | D-arginine analog for stereochemical, nitric-oxide-pathway, and synthetic research |
D Stereochemistry in Nitroarginine Research
Enzymes and receptors can discriminate strongly between L- and D-arginine derivatives. A D nitroarginine can be useful in stereochemical control experiments, comparative binding/activity studies, or routes that intentionally incorporate a D guanidino amino acid.
Related mirror-image residues can be compared in the D-form amino acid range.
Nitroguanidino Functional Group
The Nω-nitro modification changes the electronics and hydrogen-bonding behavior of the guanidino group. In biological research, this can influence interaction with arginine-utilizing enzymes; in synthesis, it also creates a chemically distinct protected/modified guanidino state.
The exact biological effect is assay dependent and should not be generalized from the L analog without direct experimental data.
Procurement and Experimental Use
CAS 66036-77-9, D stereochemistry, and nitroguanidino identity should all be confirmed because “nitroarginine” is often used loosely in literature and vendor catalogs. Lot purity and analytical data are especially important for stereochemical control studies.
Product Documents
MSDS - H-D-Arg(NO2)-OH (AS2015)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is H-D-Arg(NO2)-OH the same as Nω-nitro-L-arginine?
No. It is the D stereoisomer and should not be assumed to have the same biological activity as the L form.
What is modified in this arginine analog?
The guanidino group is Nω-nitro substituted.
Why is the D form useful?
It can support stereochemical control experiments and research on how arginine-recognizing systems discriminate configuration.