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H-Hyp-OMe·HCl is trans-4-hydroxy-L-proline methyl ester hydrochloride. The hydroxyproline carboxyl group is protected as a methyl ester, while the ring nitrogen is supplied as the hydrochloride salt and the 4-hydroxyl remains free.
This combination is useful in solution-phase synthesis because the ester masks the carboxyl terminus while leaving the nitrogen available after neutralization for N-protection, acylation, or other derivatization.
Product Information
| Product Name | H-Hyp-OMe·HCl |
| Chemical Name | trans-4-Hydroxy-L-proline methyl ester hydrochloride |
| Catalog No. | AS2068 |
| CAS No. | 40216-83-9 |
| Molecular Formula | C6H12ClNO3 |
| Molecular Weight | 181.62 g/mol |
| Compound Type | Hydroxyproline methyl ester hydrochloride |
| Primary Research Use | Chiral hydroxyproline intermediate for solution-phase synthesis |
Trans-Hydroxyproline Identity
The trans designation differentiates this compound from cis-4-hydroxy-L-proline methyl ester salts that share the same elemental composition and molecular weight. Relative stereochemistry can materially affect downstream molecular shape and biological recognition.
For chiral synthesis, the exact stereoisomer should therefore be confirmed by product name, CAS, and lot documentation rather than formula alone.
Protection State and Reactivity
The methyl ester protects the carboxyl group from many transformations at nitrogen or hydroxyl. The HCl salt provides an isolable protonated amine form; downstream reactions normally account for neutralization/base equivalents.
The 4-hydroxyl remains unprotected and may need additional protection if the next step is not chemoselective.
Use as a Chiral Intermediate
This material is useful in hydroxyproline-derived small molecules, peptidomimetic scaffolds, and specialty residue synthesis. Related stereochemical options can be explored in our unusual amino-acid range.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does OMe mean in H-Hyp-OMe·HCl?
OMe indicates that the carboxyl group is present as a methyl ester.
Is the 4-hydroxyl protected?
No. The hydroxyproline 4-OH remains free.
How is this different from H-Cis-Hyp-OMe·HCl?
They are distinct stereoisomers with different relative configuration at the hydroxyproline ring; they should not be treated as interchangeable.