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Ac-Tyr-OEt·H2O, commonly abbreviated ATEE, is N-acetyl-L-tyrosine ethyl ester monohydrate. The amino terminus is acetylated and the carboxyl group is ethyl-esterified, creating a blocked tyrosine derivative widely used as an enzyme substrate rather than as a chain-extendable amino-acid building block.
ATEE is particularly associated with chymotrypsin and related protease/esterase research. Its blocked termini help isolate cleavage chemistry at the ester-containing substrate and make it useful for enzyme-kinetics and comparative activity experiments.
Product Information
| Product Name | Ac-Tyr-OEt·H2O |
| Chemical Name | N-Acetyl-L-tyrosine ethyl ester monohydrate |
| Catalog No. | AS2014 |
| CAS No. | 36546-50-6 |
| Molecular Formula | C13H19NO5 |
| Molecular Weight | 269.29 g/mol |
| Compound Type | Blocked tyrosine ester and enzyme substrate |
| Primary Research Use | Chymotrypsin/protease substrate and enzyme-kinetics research |
ATEE as an Enzyme Substrate
N-Acetyl-L-tyrosine ethyl ester has a long history as a substrate in chymotrypsin-related kinetic studies. Assay readouts and conditions vary across methods, so substrate concentration, buffer, pH, temperature, and enzyme source should be selected from the intended protocol.
For assay-focused discovery, this product fits naturally with our enzyme substrate collection.
Why the Blocked Tyrosine Structure Matters
N-acetylation blocks the amino group and the ethyl ester caps the carboxyl terminus. This makes ATEE chemically different from a protected tyrosine residue designed for peptide-chain extension.
The phenolic tyrosine side chain remains part of the substrate identity and can contribute to recognition in aromatic-binding enzyme sites.
Monohydrate Identity and Procurement
The H2O in the product name denotes a monohydrate and is reflected in the listed formula C13H19NO5 and MW 269.29. Procurement should use the exact hydrate form, CAS 36546-50-6, and lot COA to avoid confusion with anhydrous naming conventions.
Product Documents
MSDS - Ac-Tyr-OEt·H2O (AS2014)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Frequently Asked Questions
What does ATEE stand for?
ATEE commonly refers to N-acetyl-L-tyrosine ethyl ester; this Alan Scientific product is listed as the monohydrate.
Is ATEE a peptide building block?
It is primarily a blocked tyrosine derivative used as an enzyme substrate/reference compound, not a routine chain-extendable amino-acid building block.
Why is H2O included in the name?
It indicates the monohydrate form and is included in the molecular formula and molecular weight.