$133.00 - $680.00
H-Cis-Hyp-OMe·HCl is cis-4-hydroxy-L-proline methyl ester hydrochloride, a stereodefined hydroxyproline derivative with a methyl-protected carboxyl group, protonated ring nitrogen, and free 4-hydroxyl.
The cis configuration is the defining feature of this product. Although the cis and trans methyl ester hydrochlorides have the same formula and molecular weight, their relative stereochemistry gives different three-dimensional structures and can lead to different synthetic or biological behavior.
Product Information
| Product Name | H-Cis-Hyp-OMe·HCl |
| Chemical Name | cis-4-Hydroxy-L-proline methyl ester hydrochloride |
| Catalog No. | AS2069 |
| CAS No. | 40126-30-5 |
| Molecular Formula | C6H12ClNO3 |
| Molecular Weight | 181.62 g/mol |
| Compound Type | cis-Hydroxyproline methyl ester hydrochloride |
| Primary Research Use | Stereodefined hydroxyproline intermediate for chiral synthesis |
Why the Cis Configuration Matters
Hydroxyproline derivatives are conformationally constrained by the pyrrolidine ring. Changing the relative orientation of the 4-hydroxyl creates a distinct stereochemical building block rather than a simple naming variant.
For projects that intentionally vary residue stereochemistry, other stereodefined amino acids can complement cis/trans hydroxyproline studies.
Methyl Ester and HCl Salt
The carboxyl group is masked as OMe, supporting reactions focused on the ring nitrogen or hydroxyl. The nitrogen is supplied as the hydrochloride salt and generally requires appropriate base handling before N-acylation or N-protection.
The free hydroxyl can be retained for functionalization or protected separately if the route requires orthogonality.
Selection Versus the Trans Isomer
Choose the cis material only when that stereochemistry is part of the target structure or experimental question. Procurement by formula alone is insufficient because the trans isomer has the same elemental composition.
Product Documents
MSDS - H-Cis-Hyp-OMe·HCl (AS2069)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Does H-Cis-Hyp-OMe·HCl have the same molecular weight as the trans isomer?
Yes. Cis and trans stereoisomers can share the same formula and molecular weight while remaining chemically distinct stereochemical entities.
Is the hydroxyl group protected?
No. The 4-hydroxyl remains free.
What should be checked during procurement?
Confirm the cis designation, CAS 40126-30-5, purity, and lot-specific stereochemical/analytical documentation.