$57.14 - $171.43
Fmoc-Val-Val-Val-OH is a preassembled trivaline fragment with an Fmoc-protected N-terminus and free C-terminal carboxyl.
Three consecutive β-branched valines create a strongly hydrophobic, sterically crowded sequence environment. For a shorter related fragment, compare Fmoc-Leu-Val-OH or Fmoc-Phe-Val-OH depending on the intended N-terminal residue.
Product Information
| Product Name | Fmoc-Val-Val-Val-OH |
| Catalog No. | AS4148 |
| CAS No. | 649757-37-9 |
| Molecular Formula | C30H39N3O6 |
| Molecular Weight | 537.66 g/mol |
| Material / Building Block Type | Fmoc-protected Val-Val-Val tripeptide fragment |
| Primary Applications | Hydrophobic peptide fragment synthesis; β-branched motif assembly; aggregation-prone sequence research; convergent peptide synthesis |
Application Scope in Hydrophobic Sequence Assembly
Val-rich segments are used in peptide SAR, structural motifs and hydrophobic-core models. A preformed Val3 fragment can be useful when repeated stepwise coupling of β-branched Val becomes inefficient.
Aggregation and Coupling Behavior
Consecutive Val residues can promote resin aggregation and difficult coupling because each residue is β-branched. Fragment incorporation reduces some downstream coupling cycles but the terminal Val junction can still be sterically demanding.
Procurement and QC
Confirm CAS 649757-37-9, C30H39N3O6, MW 537.66 g/mol and Val-Val-Val sequence identity. HPLC/MS should be reviewed for deletion or chain-length impurities.
For highly hydrophobic or aggregation-prone sequences, Alan Scientific can optimize assembly through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Why can Val3 be difficult to synthesize stepwise?
Consecutive β-branched residues increase steric hindrance and can promote aggregation.
Is the C-terminal carboxyl free?
Yes.
Does a preformed fragment eliminate all coupling difficulty?
No. The fragment-to-chain junction may still be demanding.