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Fmoc-L-4-Pyridylalanine (CAS 169555-95-7) is a Protected amino-acid / peptidomimetic building block used in peptide, peptidomimetic and medicinal-chemistry synthesis. Its main synthetic value is a pyridyl heteroaromatic side chain that introduces a ring nitrogen and altered polarity/basicity.
Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. Its value is route-specific, so selection should follow the intended transformation rather than the broad category label.
Product Information
| Product Name | Fmoc-L-4-Pyridylalanine |
| Catalog No. | AS4230 |
| CAS No. | 169555-95-7 |
| Molecular Formula | C23H20N2O4 |
| Molecular Weight | 388.42 g/mol |
| Compound Type | Protected amino-acid / peptidomimetic building block |
| Primary Research Use | Peptide, peptidomimetic and medicinal-chemistry synthesis |
Residue Design and Application
Fmoc-L-4-Pyridylalanine is relevant when the target structure requires a pyridyl heteroaromatic side chain that introduces a ring nitrogen and altered polarity/basicity. Its value comes from the residue identity itself, not simply from carrying a standard Fmoc or Boc group.
Protection Strategy
The protecting group controls which functionality remains available during coupling and which cleavage chemistry is required later. Check the complete protection scheme before substituting this material for a related amino acid.
Sequence-Level Decision
Use this derivative when its side chain, backbone spacing or stereochemistry is part of the design hypothesis. For routine sequences, the corresponding standard residue is usually the simpler choice.
Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.
Product Documents
MSDS - Fmoc-L-4-Pyridylalanine (AS4230)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What distinguishes Fmoc-L-4-Pyridylalanine in synthesis?
Its intended role is peptide, peptidomimetic and medicinal-chemistry synthesis, with the exact residue or functional-group state defined by the product structure.
Why check the protection map for Fmoc-L-4-Pyridylalanine?
In Fmoc-L-4-Pyridylalanine, the protection state determines which functions remain reactive and which deprotection conditions can be used later in the route.