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Fmoc-Phe-Val-OH is an Fmoc-protected Phe-Val dipeptide with an aromatic Phe residue followed by β-branched Val.
The preassembled motif is useful when aromatic packing and hydrophobicity are fixed design features and the route benefits from moving the Phe–Val peptide bond upstream into a characterized fragment.
Product Information
| Product Name | Fmoc-Phe-Val-OH |
| Catalog No. | AS4135 |
| CAS No. | 223674-40-6 |
| Molecular Formula | C29H30N2O5 |
| Molecular Weight | 486.56 g/mol |
| Material / Building Block Type | Fmoc-protected L-Phe-L-Val dipeptide fragment |
| Primary Applications | Aromatic/hydrophobic peptide SAR; Phe-Val motif installation; β-branched fragment coupling; convergent peptide synthesis |
Application Scope in Aromatic-Hydrophobic SAR
Phe contributes an aromatic ring while Val provides compact β-branched hydrophobicity. The pair can be used to probe hydrophobic pockets, membrane-facing segments and local packing in peptide analogs.
Fragment Coupling Considerations
The free C-terminal Val carboxyl supports further extension, but Val sterics can increase coupling demand. Crude HPLC should be monitored for deletion or incomplete-coupling products in longer targets.
Procurement and QC
Confirm CAS 223674-40-6, C29H30N2O5, MW 486.56 g/mol, Phe-Val sequence and L stereochemistry.
Alan Scientific can evaluate fragment versus stepwise assembly through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is the sequence direction?
Phe-Val.
Is the terminal carboxyl free?
Yes.
What is the main application?
Aromatic/hydrophobic motif installation in peptide SAR and convergent synthesis.
Related Technical Resources
Review practical peptide assembly