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Fmoc-Leu-Val-OH is an Fmoc-protected Leu-Val dipeptide with a free C-terminal Val carboxyl group.
The fragment combines a flexible hydrophobic Leu side chain with a β-branched Val terminus and is useful when the Leu-Val sequence is fixed across a series or when one difficult junction is better prepared upstream.
Product Information
| Product Name | Fmoc-Leu-Val-OH |
| Catalog No. | AS4140 |
| CAS No. | 158739-04-9 |
| Molecular Formula | C26H32N2O5 |
| Molecular Weight | 452.55 g/mol |
| Material / Building Block Type | Fmoc-protected L-Leu-L-Val dipeptide fragment |
| Primary Applications | Hydrophobic dipeptide fragment coupling; Leu-Val motif installation; β-branched peptide assembly; peptide SAR libraries |
Application Scope in Hydrophobic Peptide SAR
Leu-Val motifs are common hydrophobic sequence elements and can be used to tune side-chain packing, membrane interaction or receptor-pocket occupancy in peptide analogs.
β-Branched Terminal Coupling
The C-terminal Val can make fragment coupling more sterically demanding than a Gly-terminated fragment. Activation conditions should balance complete conversion against epimerization and side-product formation.
Procurement and QC
Confirm CAS 158739-04-9, C26H32N2O5, MW 452.55 g/mol, sequence direction Leu-Val and L stereochemistry.
For hydrophobic or β-branched targets, Alan Scientific can provide custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is Leu-Val the same as Val-Leu?
No.
Why use a preformed dipeptide?
To fix sequence identity and potentially remove one downstream coupling step.
Can Val make coupling slower?
Yes, β-branching can increase steric demand.
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