$369.00 - $1846.00
Fmoc-D-Ala-OH, also known as Fmoc-D-alanine, is an Fmoc-protected D-alanine building block used in Fmoc solid-phase peptide synthesis (SPPS). The Fmoc group protects the alpha-amino functionality while the carboxylic acid remains available for activation and coupling. Alanine has no reactive side-chain functional group, so no additional side-chain protection is normally required.
This reagent is selected when a peptide requires D-alanine rather than conventional L-alanine. Because the D- and L-enantiomers have the same molecular formula and molecular weight, purchasing and QC should rely on CAS identity, stereochemical assignment and, when relevant, enantiomeric purity rather than molecular weight or routine HPLC purity alone.
Product Information
| Product Name | Fmoc-D-Ala-OH |
| Catalog No. | AS3041 |
| CAS No. | 79990-15-1 |
| Molecular Formula | C18H17NO4 |
| Molecular Weight | 311.33 g/mol |
| Protecting Groups | Fmoc alpha-amino protection; no side-chain protecting group |
| Primary Application | D-alanine incorporation in Fmoc-SPPS |
Application Scope and Assay Relevance
Primary use: Synthetic building block for introducing D-alanine into peptides; the protected Fmoc reagent itself is not normally used as a direct biological test article.
| Typical in vitro relevance | After incorporation and deprotection, D-Ala-containing peptides are used in stereochemical SAR, receptor-binding or functional assays, protease/serum-stability studies and conformational comparisons. D-Ala-containing opioid peptides such as dermorphin and deltorphin illustrate how a single D-residue can materially change receptor recognition. |
| In vivo relevance | Applicable to the final peptide when that sequence has been validated for animal studies. D-Ala substitution may improve proteolytic stability in some sequences, but it does not by itself predict exposure, efficacy or toxicity in vivo. |
D-Ala vs L-Ala: same mass, different stereochemistry
Fmoc-D-Ala-OH and Fmoc-L-Ala-OH are enantiomeric building blocks with the same formula and molecular weight. Chiral identity is therefore a separate QC question from ordinary chemical purity.
Purchasing and QC Considerations
For stereochemistry-sensitive projects, review the exact CAS number, lot-specific HPLC purity, enantiomeric purity where available, water content and COA. Consult the product-specific MSDS for handling, storage and disposal information.
Frequently Asked Questions
What is Fmoc-D-Ala-OH used for?
It is used to introduce D-alanine during Fmoc solid-phase peptide synthesis.
Does D-alanine need side-chain protection?
No. The alanine methyl side chain normally requires no additional protection.
Can molecular weight distinguish D- and L-alanine derivatives?
No. The enantiomers have the same molecular formula and molecular weight.
Product Documents
A Material Safety Data Sheet (MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Related Technical Resources
See Fmoc-Ala-OH for a closely related building block or synthesis resource.
Browse the complete D-Form Amino Acids category or use Alan Scientific's Chemical Peptide Synthesis service for custom peptides containing D-amino acids.