$769.00 - $13846.00
Fmoc-D-Leu-OH is an Fmoc-protected D-leucine building block used for D-Leu incorporation in solid-phase peptide synthesis. Leucine has a hydrophobic isobutyl side chain and normally requires no additional side-chain protection during standard Fmoc chemistry.
D-Leu is useful in stereochemical scanning, partially D-configured peptides and peptide stability studies. A practical procurement issue is that Fmoc-D-Leu-OH and Fmoc-D-Ile-OH have the same molecular formula and molecular weight despite different side-chain connectivity, so CAS identity and structural assignment are more informative than mass alone.
Product Information
| Product Name | Fmoc-D-Leu-OH |
| Catalog No. | AS3042 |
| CAS No. | 114360-54-2 |
| Molecular Formula | C21H23NO4 |
| Molecular Weight | 353.41 g/mol |
| Protecting Groups | Fmoc alpha-amino protection; no side-chain protecting group |
| Primary Application | D-leucine incorporation in Fmoc-SPPS |
Application Scope and Assay Relevance
Primary use: Fmoc-SPPS building block for introducing D-leucine into hydrophobic or receptor-active peptide sequences.
| Typical in vitro relevance | D-Leu has been used in opioid-peptide SAR, receptor-binding and tissue bioactivity assays. More generally, downstream studies include receptor affinity, enzyme/protease stability and conformational effects of replacing L-Leu with D-Leu. |
| In vivo relevance | D-Leu-containing final peptides can be evaluated in animal pharmacology or stability studies, but activity can increase, decrease or change selectivity depending on residue position. |
D-Leu and D-Ile have the same MW
The two protected amino acids are constitutional side-chain isomers with the same formula and molecular weight. LC-MS mass alone cannot establish which building block is present.
Purchasing and QC Considerations
Confirm CAS 114360-54-2 and chiral identity. Reference peptide-synthesis grades commonly specify enantiomeric purity separately from HPLC purity and report clear DMF solubility.
Frequently Asked Questions
What is Fmoc-D-Leu-OH used for?
It is used to incorporate D-leucine during Fmoc-SPPS.
Does D-Leu require side-chain protection?
No. The hydrocarbon side chain is normally left unprotected.
Can mass distinguish D-Leu from D-Ile?
No. The protected derivatives have the same formula and molecular weight.
Product Documents
A Material Safety Data Sheet (MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Related Technical Resources
See Fmoc-D-Ile-OH for a closely related building block or synthesis resource.
Browse the complete D-Form Amino Acids category or use Alan Scientific's Chemical Peptide Synthesis service for custom peptides containing D-amino acids.