$400.00 - $2154.00
Fmoc-D-Pro-OH is an Fmoc-protected D-proline building block used in solid-phase peptide synthesis. Proline’s pyrrolidine ring links the side chain back to the backbone nitrogen, giving the residue a conformational profile that differs substantially from most other alpha-amino acids.
D-Pro can be used to introduce defined turns, alter backbone geometry or create stereochemical analogs of proline-containing sequences. Because proline coupling and downstream conformation can be sequence-dependent, D-Pro is often selected as a structural design element rather than simply as a mirror-image substitution.
Product Information
| Product Name | Fmoc-D-Pro-OH |
| Catalog No. | AS3034 |
| CAS No. | 101555-62-8 |
| Molecular Formula | C20H19NO4 |
| Molecular Weight | 337.37 g/mol |
| Protecting Groups | Fmoc protection on the proline ring nitrogen; no side-chain protection |
| Primary Application | D-proline incorporation and conformational design in Fmoc-SPPS |
Application Scope and Assay Relevance
Primary use: Conformationally influential D-proline building block used to introduce turns and restrict local backbone geometry in peptides.
| Typical in vitro relevance | D-Pro is widely used to nucleate beta-turns and beta-hairpins. Relevant assays include CD/NMR structural analysis, protease-degradation assays, antimicrobial MIC testing, membrane interaction, hemolysis and cell-selectivity studies for designed hairpin peptides. |
| In vivo relevance | D-Pro-containing final peptides may proceed to in vivo efficacy or stability testing when the designed conformation retains biological activity. Structural stabilization alone does not guarantee improved in vivo performance. |
D-Pro is a strong conformational design element
The cyclic proline backbone restricts phi-angle freedom. Reversing the proline stereochemistry can therefore produce pronounced local conformational changes in turns and constrained motifs.
Purchasing and QC Considerations
Confirm CAS 101555-62-8, chiral purity and lot-specific assay. Reference suppliers report this product specifically for Fmoc-SPPS and peptide synthesis.
Frequently Asked Questions
What is unusual about proline?
Its side chain closes back onto the backbone nitrogen, restricting local backbone conformation.
Does D-Pro need side-chain protection?
No additional side-chain protecting group is normally required.
Why use D-Pro?
It is often used to alter turn geometry, conformational preference and stereochemical recognition.
Product Documents
A Material Safety Data Sheet (MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Related Technical Resources
See D-Form Amino Acids for a closely related building block or synthesis resource.
Browse the complete D-Form Amino Acids category or use Alan Scientific's Chemical Peptide Synthesis service for custom peptides containing D-amino acids.