Endothelin-1, human is a 21-amino-acid vasoactive peptide produced by endothelial cells, acting as a potent vasoconstrictor and regulator of vascular tone. It binds to ETA and ETB receptors on vascular smooth muscle and endothelial cells, mediating vasoconstriction, cell proliferation, inflammation, and fibrosis. In humans, it plays critical roles in blood pressure regulation, cardiovascular homeostasis, and pathological conditions like hypertension, pulmonary fibrosis, and atherosclerosis. In pharmacological research, human Endothelin-1 serves as a tool to investigate receptor activation mechanisms, structure-activity relationships, and therapeutic development for cardiovascular and fibrotic disorders. Its bioactivity and disease relevance make it a key target for drug discovery, including endothelin receptor antagonists for hypertension and pulmonary arterial hypertension.

Chemical Formula: C109H159N25O32S5

Molecular Weight: 2491.95

Sequence: Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfidebridge:Cys1-Cys15,-Cys3-Cys11)

Purity: From crude to 98%

If there are no products available iwth the required purity and quantity, please inform us of your specifications and send an email to sales@alanscientific.com

Our representitives will respond within 24 hours

Research Use Only