Endothelin-1 (11-21) is a C-terminal fragment of the 21-amino-acid endothelin-1 peptide, retaining critical residues for binding to ETA and ETB receptors. This bioactive segment mediates vasoconstriction, cell proliferation, and inflammatory responses, contributing to cardiovascular regulation and pathological conditions like hypertension and pulmonary fibrosis. In pharmacological research, it serves as a tool to investigate endothelin receptor activation mechanisms, structure-activity relationships, and therapeutic development for vascular disorders. Its receptor-binding specificity and role in fibrosis make it valuable for studies on endothelial dysfunction, organ remodeling, and targeted drug delivery strategies.

Chemical Formula: C68H92N14O15S2

Molecular Weight: 1409.70

Sequence: Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp(DisulfidebridgeCys1-Cys5)

Purity: From crude to 98%

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Research Use Only