$180.00 - $1613.00
cis-4-Fluoro-L-Pro-OH is the unprotected cis-4-fluoro analog of L-proline. The fluorine substituent introduces a strong stereoelectronic perturbation without adding a bulky side chain.
The corresponding terminal amide derivative Boc-cis-4-F-Pro-NH2 serves a different synthetic purpose; AS2076 retains the free carboxylic acid.
Product Information
| Product Name | cis-4-Fluoro-L-Pro-OH |
| Catalog No. | AS2076 |
| CAS No. | 2438-57-5 |
| Molecular Formula | C5H8FNO2 |
| Molecular Weight | 133.12 g/mol |
| Material / Building Block Type | Unprotected cis-4-fluoro-L-proline |
| Primary Applications | Fluoroproline conformational studies; precursor to protected fluoroproline monomers; peptide SAR; ring-puckering research |
Application Scope in Fluoroproline Conformational Studies
4-Fluorination can bias pyrrolidine ring pucker and influence neighboring peptide-bond geometry. The cis isomer is useful for matched fluoroproline studies where ring stereochemistry is a controlled variable.
Precursor to Route-Specific Protected Monomers
Because the amino group is unprotected, AS2076 can be converted into Fmoc-, Boc- or other route-specific derivatives before peptide assembly. This makes it a flexible starting material for custom protection strategies.
Procurement and QC
Confirm CAS 2438-57-5, C5H8FNO2, MW 133.12 g/mol, L configuration and cis-4-fluoro stereochemistry. Mass cannot distinguish cis/trans or enantiomeric forms.
Alan Scientific can incorporate cis-4-fluoroproline into matched analog series through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is the amino group protected?
No.
Why use cis-4-fluoroproline?
To probe fluorine-driven ring conformation and peptide stereoelectronic effects.
Can LC-MS distinguish cis and trans isomers?
Not by mass alone.
Related Technical Resources
Read about noncanonical amino-acid design