Fmoc-L-Homophenylalanine (CAS 132684-59-4) is a Protected amino-acid / peptidomimetic building block used in peptide, peptidomimetic and medicinal-chemistry synthesis. Its main synthetic value is a homologated or beta-amino-acid framework that changes backbone spacing and conformational preferences.

Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. Its value is route-specific, so selection should follow the intended transformation rather than the broad category label.

Product Information

Residue Design and Application

Fmoc-L-Homophenylalanine is relevant when the target structure requires a homologated or beta-amino-acid framework that changes backbone spacing and conformational preferences. Its value comes from the residue identity itself, not simply from carrying a standard Fmoc or Boc group.

Protection Strategy

The protecting group controls which functionality remains available during coupling and which cleavage chemistry is required later. Check the complete protection scheme before substituting this material for a related amino acid.

Sequence-Level Decision

Use this derivative when its side chain, backbone spacing or stereochemistry is part of the design hypothesis. For routine sequences, the corresponding standard residue is usually the simpler choice.

Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.

Product Documents

MSDS - Fmoc-L-Homophenylalanine (AS4210)

The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

Why does the exact derivative matter?

Fmoc-L-Homophenylalanine is selected for its defined functional groups and protection pattern; related forms can require different coupling or deprotection conditions.

Can a close analog replace Fmoc-L-Homophenylalanine?

Not safely by name alone. For Fmoc-L-Homophenylalanine, compare stereochemistry, protecting groups, salt/ester form and the intended downstream transformation.

What should procurement verify?

Match the product to CAS 132684-59-4 and the lot-specific COA rather than relying only on a shorthand chemical name.

Research Use Only.