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Boc-cis-4-F-Pro-NH2 is a cis-4-fluoroproline derivative in which the ring nitrogen is Boc-protected and the carboxyl group has been converted to a primary amide.
For a free-acid precursor that can be converted into protected derivatives, compare cis-4-Fluoro-L-Pro-OH.
Product Information
| Product Name | Boc-cis-4-F-Pro-NH2 |
| Catalog No. | AS2078 |
| CAS No. | 426844-22-6 |
| Molecular Formula | C10H17FN2O3 |
| Molecular Weight | 232.25 g/mol |
| Material / Building Block Type | Boc-protected cis-4-fluoroproline carboxamide |
| Primary Applications | Fluoroproline peptide SAR; terminal prolinamide motif synthesis; conformational studies; peptidomimetic intermediate chemistry |
Application Scope in Fluoroproline SAR
4-Fluoroproline can alter pyrrolidine ring puckering and local peptide conformation through stereoelectronic effects. The cis fluorine configuration provides a defined conformational perturbation.
Terminal Amide Changes Synthetic Function
Because the carboxyl is already CONH2, this reagent is suited to terminal prolinamide motifs or intermediate chemistry rather than ordinary chain extension through a free carboxyl.
Procurement and QC
Confirm CAS 426844-22-6, C10H17FN2O3, MW 232.25 g/mol, cis fluorine configuration and primary carboxamide identity.
For fluoroproline analog series or terminal prolinamide designs, Alan Scientific can provide custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is the carboxyl group free?
No. It is a primary amide.
What is the main stereochemical feature?
cis-4-fluoro substitution on the proline ring.
Can this be used as a normal peptide-coupling free acid?
No.