Fmoc-3,4-Dehydro-l-Proline (CAS 135837-63-7) is supplied as a Protected amino-acid / peptidomimetic building block. In research synthesis, it is most relevant to peptide, peptidomimetic and medicinal-chemistry synthesis and a conformationally constrained backbone framework for structure-focused peptide design.

Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.

Product Information

Application in Peptide and Peptidomimetic Design

Fmoc-3,4-Dehydro-l-Proline expands accessible chemical space through a conformationally constrained backbone framework for structure-focused peptide design. This makes the product most relevant to sequence-defined SAR, conformational studies or specialized synthetic targets.

What to Check Before Incorporation

Confirm stereochemistry, free versus protected functional groups and the planned cleavage sequence. These details affect activation choice, solubility and the identity of the final residue.

Procurement Relevance

Use CAS 135837-63-7 together with the full product name when comparing suppliers. Similar shorthand names can refer to different positional isomers or protection states.

Additional chemistry is available in the specialty amino acid set. For synthesis planning beyond the building block, see specialty SPPS building blocks.

Product Documents

MSDS - Fmoc-3,4-Dehydro-l-Proline (AS4216)

The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

Why does the exact derivative matter?

Fmoc-3,4-Dehydro-l-Proline is selected for its defined functional groups and protection pattern; related forms can require different coupling or deprotection conditions.

Can a close analog replace Fmoc-3,4-Dehydro-l-Proline?

Not safely by name alone. For Fmoc-3,4-Dehydro-l-Proline, compare stereochemistry, protecting groups, salt/ester form and the intended downstream transformation.

What should procurement verify?

Match the product to CAS 135837-63-7 and the lot-specific COA rather than relying only on a shorthand chemical name.

Research Use Only.