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Angiotensin II acetate, human is the acetate salt of the eight-residue endogenous RAAS peptide Angiotensin II. Its sequence, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe (DRVYIHPF), engages angiotensin type 1 and type 2 receptors and is widely used in cardiovascular, renal and GPCR signaling research.
Product Information
| Property | Specification |
|---|---|
| Product Name | Angiotensin II Acetate, Human |
| CAS No. | 68521-88-0 |
| Sequence | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe |
| One-Letter Sequence | DRVYIHPF |
| Peptide Length | 8 amino acids |
| Peptide Backbone MW | Approximately 1046.2 Da |
| Salt Form | Acetate |
| Reference MW with Acetate | Approximately 1106.2 Da |
| Primary Targets | AT1R and AT2R |
| Research Areas | RAAS signaling, vascular biology, renal physiology, GPCR pharmacology |
AT1R and AT2R Signaling
Angiotensin II interacts with two major GPCR subtypes, AT1R and AT2R. AT1R mediates many of the classical Angiotensin II responses studied in vascular smooth muscle, adrenal and renal systems, while AT2R has a distinct signaling profile and tissue distribution.
Modern structural studies of human angiotensin receptors have resolved how Angiotensin II-related peptide ligands occupy the receptor-binding cavity and how ligand recognition is coupled to downstream receptor activation.
Sequence–Function Relationships
The short DRVYIHPF sequence contains several residues that are highly sensitive to substitution. In particular, the C-terminal Phe8 occupies the deep region of the angiotensin receptor ligand-binding pocket and contributes strongly to receptor activation.
This makes native Angiotensin II useful as a reference scaffold when evaluating truncations, residue substitutions or biased agonist designs.
Acetate Salt and Quantitative Experiments
The peptide backbone and acetate counterion should be distinguished when molecular weight, concentration or net peptide content is calculated.
We recommend using lot-specific peptide content and counterion information for quantitative receptor assays instead of calculating molarity solely from nominal vial mass.
Researchers can review our Recommended Peptide Purity guidance when selecting material for receptor or cell-based studies.
Frequently Asked Questions
How many residues are in human Angiotensin II?
Human Angiotensin II contains eight residues with the sequence DRVYIHPF.
What is the difference between Angiotensin II and Angiotensin II acetate?
The peptide sequence is the same, but the acetate product contains acetate as a counterion. This distinction can affect molecular-weight and peptide-content calculations.