$214.29 - $642.86
Z-Val-Ala-OH is Cbz-L-Val-L-Ala-OH, a protected dipeptide with a free C-terminal alanine carboxyl group. It provides a preformed Val-Ala bond for fragment coupling, convergent assembly and preparation of sequence-specific peptide intermediates.
The fragment is more than a generic dipeptide. Valine is β-branched, which increases steric demand near the peptide backbone. Moving the Val-Ala bond into a precharacterized starting material can be useful when a route is designed to avoid forming that bond at a later, more crowded stage.
Product Information
| Product Name | Z-Val-Ala-OH |
| Catalog No. | AS4094 |
| CAS No. | 24787-89-1 |
| Molecular Formula | C16H22N2O5 |
| Molecular Weight | 322.36 g/mol |
| Chemical Identity | Cbz-L-Val-L-Ala-OH |
| Building Block Type | Cbz-protected dipeptide fragment |
| Primary Applications | Protected-fragment synthesis, convergent peptide assembly, Val-Ala intermediates and route development |
Why the Val-Ala Bond Can Be Worth Preassembling
Valine’s β-branched isopropyl side chain creates more steric congestion than alanine. A preformed Val-Ala fragment removes this particular coupling from the downstream sequence. We consider the advantage greatest when the motif is repeated across analogs or when later-stage assembly is already sterically demanding.
A Preformed Fragment Does Not Eliminate Sequence Difficulty
The fragment solves only the bond already present in Z-Val-Ala-OH. Longer Val-rich or hydrophobic sequences can still show poor resin solvation, aggregation and difficult subsequent couplings. Our guide to incomplete coupling and aggregation in SPPS explains why a clean building block does not automatically guarantee a clean full-length peptide.
Val-Ala vs Val-Pro Is a Useful Structural Contrast
For projects comparing neighboring short motifs, Z-Val-Pro-OH replaces the flexible C-terminal alanine residue with conformationally restricted proline. The two fragments therefore offer a simple contrast between a conventional Val-Ala backbone and a Val-Pro motif with proline-specific geometry.
Procurement and QC Considerations
Confirm CAS 24787-89-1, C16H22N2O5, MW 322.36 g/mol and L-Val-L-Ala stereochemistry. If stereoisomeric fragments are part of the same project, routine mass confirmation should be supplemented with structure-specific documentation because nominal mass does not prove configuration.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Does Z-Val-Ala-OH contain two L-amino acids?
Yes. The intended identity is Cbz-L-Val-L-Ala-OH.
Why use the dipeptide instead of separate Val and Ala residues?
It removes one downstream coupling and provides a separately characterized Val-Ala motif.
Can the C-terminal alanine be extended?
Yes. Its carboxyl group is free and can be activated for additional amide-bond formation.
Related Technical Resources
For complete Val-containing sequences, including difficult or modified targets, see our custom peptide synthesis service.