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Fmoc-β-Homo-Leu-OH is a β-amino-acid homolog of leucine, adding one backbone methylene relative to the corresponding α-amino-acid architecture.
That backbone extension changes the spacing between peptide-bond-forming groups and can create conformational behavior not accessible from ordinary Leu substitutions.
Product Information
| Product Name | Fmoc-β-Homo-Leu-OH |
| Catalog No. | AS2133 |
| CAS No. | 193887-44-4 |
| Molecular Formula | C22H25NO4 |
| Molecular Weight | 367.44 g/mol |
| Material / Building Block Type | Fmoc-protected β-homoleucine |
| Primary Applications | β-Peptide and peptidomimetic synthesis; backbone-homologated SAR; protease-stability studies; noncanonical peptide libraries |
Application Scope in β-Peptides
β-Homo-Leu can be incorporated into β-peptides or mixed α/β sequences to alter folding, protease resistance and hydrophobic packing. It is useful in peptidomimetic libraries where backbone geometry is itself an SAR variable.
Backbone Homologation and Sequence Design
Adding one backbone carbon increases conformational freedom and changes amide spacing. The effect on helicity or binding depends on neighboring α/β residues and cannot be predicted from hydrophobicity alone.
Procurement and QC
Confirm CAS 193887-44-4, C22H25NO4, MW 367.44 g/mol and the β-amino-acid connectivity. Structural identity is more informative than the shorthand 'Homo-Leu'.
For α/β hybrid peptides and peptidomimetics, Alan Scientific can support custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does β-Homo-Leu mean?
A leucine-related β-amino-acid homolog with an extra backbone methylene.
Why use β-amino acids?
To alter backbone geometry and often improve resistance to standard proteases.
Is it interchangeable with Fmoc-Leu-OH?
No.
Related Technical Resources
Explore noncanonical amino-acid design