Fmoc-1,4-cis-ACHC-OH (CAS 147900-45-6) is a Protected amino-acid / peptidomimetic building block used in peptide, peptidomimetic and medicinal-chemistry synthesis. Its main synthetic value is a constrained or cycloalkyl side chain used to probe hydrophobic packing and conformation.

Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. The most relevant purchasing decision is whether this exact derivative removes a known synthetic constraint in the planned sequence or small-molecule route.

Product Information

Residue Design and Application

Fmoc-1,4-cis-ACHC-OH is relevant when the target structure requires a constrained or cycloalkyl side chain used to probe hydrophobic packing and conformation. Its value comes from the residue identity itself, not simply from carrying a standard Fmoc or Boc group.

Protection Strategy

The protecting group controls which functionality remains available during coupling and which cleavage chemistry is required later. Check the complete protection scheme before substituting this material for a related amino acid.

Sequence-Level Decision

Use this derivative when its side chain, backbone spacing or stereochemistry is part of the design hypothesis. For routine sequences, the corresponding standard residue is usually the simpler choice.

Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.

Product Documents

MSDS - Fmoc-1,4-cis-ACHC-OH (AS4222)

The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

Why does the exact derivative matter?

Fmoc-1,4-cis-ACHC-OH is selected for its defined functional groups and protection pattern; related forms can require different coupling or deprotection conditions.

Can a close analog replace Fmoc-1,4-cis-ACHC-OH?

Not safely by name alone. For Fmoc-1,4-cis-ACHC-OH, compare stereochemistry, protecting groups, salt/ester form and the intended downstream transformation.

What should procurement verify?

Match the product to CAS 147900-45-6 and the lot-specific COA rather than relying only on a shorthand chemical name.

Research Use Only.