N-Fmoc-N-hexyl-glycine (CAS 1374785-50-8) belongs to the fmoc-protected N-hexylglycine building block class. It is used in n-substituted glycine and peptidomimetic synthesis, particularly where N-alkyl glycine incorporation, peptoid-like design and hydrophobic side-chain exploration is required.

Use it when the target specifically calls for N-hexylglycine; it is an N-substituted glycine derivative rather than a conventional alpha-amino-acid side-chain analog. The most relevant purchasing decision is whether this exact derivative removes a known synthetic constraint in the planned sequence or small-molecule route.

Product Information

N-Substituted Glycine Design

N-Fmoc-N-hexyl-glycine is an N-alkyl glycine derivative carrying a hexyl substituent on nitrogen. This places the hydrophobic group on the amide nitrogen after incorporation, a structural pattern associated with N-substituted glycine and peptoid-like chemistry rather than a conventional amino-acid side chain.

Hydrophobic and Conformational Effects

The N-hexyl group increases hydrophobic character and removes a backbone N-H after incorporation. These changes can be useful in peptidomimetic design where backbone hydrogen bonding and side-chain presentation are being altered deliberately.

Assembly Considerations

N-substituted glycine derivatives can be more sterically demanding than primary amino-acid building blocks. Coupling efficiency, solubility and the behavior of the deprotected secondary amine should be evaluated in the actual sequence context.

Compare neighboring reagents in our noncanonical amino acids. Full-sequence work is covered under protected peptide building blocks.

Product Documents

MSDS - N-Fmoc-N-hexyl-glycine (AS4217)

The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What makes N-Fmoc-N-hexyl-glycine different from a standard amino acid?

The hexyl substituent is attached to the glycine nitrogen, giving an N-substituted glycine architecture rather than a conventional alpha-amino-acid side chain.

What does the N-hexyl group change?

It increases hydrophobic character and, after incorporation, removes a backbone N-H at that position.

Can coupling require optimization?

Yes. N-substituted glycine derivatives can be more sterically demanding, so sequence-specific coupling conditions should be evaluated.

Research Use Only.