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[Nle10]-Neurokinin A (4-10) is a seven-residue analog of the C-terminal active fragment of Neurokinin A. The native C-terminal methionine is replaced by norleucine while the remaining NKA(4-10) sequence is preserved.
The peptide is a classical selective NK2 receptor agonist and is useful for investigating how the C-terminal hydrophobic residue contributes to Neurokinin A recognition and receptor activation.
Product Information
| Product Name | [Nle10]-Neurokinin A (4-10) |
| Catalog No. | AS2560 |
| CAS No. | 110863-33-7 |
| Sequence | Asp-Ser-Phe-Val-Gly-Leu-Nle-NH2 |
| Short Sequence | DSFVGL-Nle-NH2 |
| Peptide Length | 7 residues |
| Molecular Formula | C35H56N8O10 |
| Molecular Weight | Approximately 748.9 Da |
| Key Substitution | Met10 → Nle |
| C-Terminus | Amidated |
| Pharmacological Profile | Selective NK2 receptor agonist |
| Purity Options | Crude to 98% |
Met10 to Norleucine Substitution
Norleucine is a hydrophobic, non-sulfur-containing analog of methionine. Replacing Met10 with Nle preserves a similar hydrophobic side-chain length while removing the thioether group that is susceptible to oxidation.
This makes [Nle10]-NKA(4-10) particularly useful when researchers want to retain a C-terminal hydrophobic residue without the oxidation liability associated with methionine.
NK2 Receptor Pharmacology
Structure–activity studies of Neurokinin A identified [Nle10]-NKA(4-10) as one of the most selective peptide agonists for the NK2 receptor system. The C-terminal NKA(4-10) fragment contains much of the structural information required for NK2 activation, making residue 10 an informative position for analog design.
We consider the Nle10 substitution especially useful in comparisons involving peptide storage or repeated solution handling because oxidation is no longer possible at the terminal residue. It does not, however, make the entire peptide inherently resistant to all enzymatic degradation pathways.
Research Applications
[Nle10]-Neurokinin A (4-10) can be used in NK2 receptor functional assays, smooth-muscle pharmacology, tachykinin receptor subtype studies and Neurokinin A structure–activity research.
It is also useful as a comparator for native NKA(4-10) when evaluating whether methionine oxidation or C-terminal side-chain chemistry affects an experimental result.
Frequently Asked Questions
What does Nle10 mean?
The native methionine at position 10 of Neurokinin A is replaced with norleucine.
Is [Nle10]-NKA(4-10) an NK2 agonist?
Yes. It was identified in classical structure–activity studies as a selective NK2 receptor agonist.
Why replace methionine with norleucine?
Norleucine provides a similar hydrophobic side chain without sulfur, eliminating methionine oxidation at the C-terminal position.
Is the peptide amidated?
Yes. It terminates in Nle-NH2.