Porcine β-Endorphin is a 31-residue endogenous opioid peptide derived from the porcine POMC/β-lipotropin pathway. It retains the conserved Tyr-Gly-Gly-Phe-Met opioid motif while containing a species-specific C-terminal sequence distinct from human, rat and several other mammalian β-Endorphins.

The peptide is particularly useful for swine pituitary-processing studies and comparative analysis of naturally occurring β-Endorphin sequences.

Product Information

A Single Natural Substitution Distinguishes the Porcine Sequence

Porcine β-Endorphin differs from the camel/bovine-like sequence at position 23, where Val replaces Ile. The remaining C-terminal His27 and Gln31 residues are characteristic of several non-human mammalian forms.

This creates a useful natural structure–activity comparison in which most of the 31-residue scaffold is conserved while a single hydrophobic side chain changes.

Sequential Processing in Porcine Pituitary

Classical porcine pituitary studies showed that full-length β-Endorphin(1-31) can be generated from β-lipotropin before subsequent C-terminal processing produces shorter β-Endorphin-related products.

This makes the intact porcine peptide particularly relevant to precursor-processing experiments rather than only receptor activation assays.

Research Applications

Porcine β-Endorphin can support opioid receptor pharmacology, pituitary peptide processing, endocrine-cell research, species comparisons and analytical studies of β-Endorphin-related fragments.

For custom truncations or species variants, researchers can use our Chemical Peptide Synthesis capabilities.

Frequently Asked Questions

Is porcine β-Endorphin the same sequence as human β-Endorphin?

No. Several residues toward the C-terminus differ, including Val23, His27 and Gln31 in the porcine sequence.

Why use the porcine peptide?

It is useful for species-matched swine studies and for investigating POMC-derived peptide processing in porcine pituitary or endocrine systems.

Research Use Only.