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Neurokinin A (4-10) is a seven-residue C-terminal fragment of Neurokinin A with the sequence Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂. It retains the conserved tachykinin C-terminal region responsible for much of the receptor-recognition activity of the parent peptide.
The fragment provides a compact scaffold for NK2 receptor pharmacology and for determining which portions of the full Neurokinin A sequence are required for ligand activity.
Product Information
| Property | Specification |
|---|---|
| Product Name | Neurokinin A (4-10) |
| CAS No. | 97559-35-8 |
| Sequence | Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂ |
| One-Letter Sequence | DSFVGLM-NH₂ |
| Peptide Length | 7 residues |
| Molecular Formula | C34H54N8O10S |
| Molecular Weight | Approximately 766.9 Da |
| C-Terminus | Met-NH₂ |
| Research Context | NK2 receptor pharmacology and tachykinin SAR |
The Conserved Tachykinin C-Terminus
The sequence contains the Phe-X-Gly-Leu-Met-NH₂ motif characteristic of mammalian tachykinins. Removal of the first three NKA residues produces a shorter ligand while retaining this receptor-facing region.
It therefore provides a useful starting scaffold for β-Ala substitutions, D-amino-acid antagonists and other NK2-directed analog designs.
Full-Length NKA Versus NKA (4-10)
Full-length Neurokinin A contains His-Lys-Thr before the seven-residue fragment. Comparing the two peptides can help distinguish contributions from the N-terminal extension versus the conserved C-terminal pharmacophore.
The full endogenous ligand is available as Neurokinin A.
Frequently Asked Questions
How many residues are in NKA (4-10)?
Seven residues.
Is its C-terminus amidated?
Yes. The peptide terminates in Met-NH₂.