Neurokinin B (NKB) is a 10-residue endogenous tachykinin and the principal endogenous agonist of the neurokinin-3 receptor (NK3R). The mature sequence is Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH₂.

Beyond classical tachykinin receptor pharmacology, NKB has become an important molecular tool for investigating hypothalamic KNDy neuronal networks and regulation of pulsatile reproductive neuroendocrine signaling.

Product Information

Principal Endogenous NK3 Receptor Ligand

NKB can interact with all three major tachykinin receptors, but its highest endogenous receptor preference is generally associated with NK3R. Human pharmacological data show substantially stronger NK3 activity than NK1 activity.

For subtype-specific experiments, receptor expression and species should still be documented because tachykinins display overlapping pharmacology.

NKB in the KNDy Network

Neurokinin B is coexpressed with kisspeptin and dynorphin in hypothalamic KNDy neurons. Current evidence supports NKB-NK3R signaling as an important stimulatory component involved in synchronization of this neuronal network and regulation of pulsatile GnRH output.

This makes the peptide relevant not only to conventional tachykinin pharmacology but also to reproductive neuroendocrine and hypothalamic circuit research.

Two Methionines Require Analytical Attention

NKB contains Met2 and Met10. Oxidation of either residue can generate molecular species with altered mass and potentially altered receptor behavior.

For quantitative signaling studies, we recommend monitoring molecular identity together with chromatographic purity.

Frequently Asked Questions

Which receptor is most closely associated with Neurokinin B?

NK3R is its principal endogenous receptor, although NKB can show activity at NK1 and NK2 receptors at different concentrations.

Is Neurokinin B part of the KNDy system?

Yes. NKB is one of the three defining neuropeptides of kisspeptin/neurokinin B/dynorphin neurons.

Research Use Only.