α-Neo-Endorphin Analog is a synthetic 11-residue derivative of the α-Neoendorphin scaffold with the sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Arg-Pro-Lys-NH₂.

The construct preserves the N-terminal Leu-enkephalin motif while replacing the native C-terminal arrangement with an Arg-Pro-Lys extension and terminal amidation.

Product Information

C-Terminal Engineering

The native α-Neoendorphin sequence ends in Tyr-Pro-Lys-OH. This analog introduces Arg immediately after Tyr8 and terminates with an amidated Lys.

These changes modify both charge distribution and terminal chemistry, making the peptide useful for studies focused on the receptor-address region rather than as a replacement for native α-Neoendorphin.

Designed Analog, Not an Endogenous Sequence

We recommend identifying this material explicitly as a synthetic analog. Its extended sequence and C-terminal amide distinguish it chemically from the naturally occurring 10-residue prodynorphin product.

Research Applications

The peptide can support opioid sequence–activity studies, terminal-modification experiments, receptor-binding comparisons and investigation of how basic residues influence prodynorphin-derived peptide behavior.

Frequently Asked Questions

Is this identical to endogenous α-Neoendorphin?

No. It contains an additional Arg in the C-terminal region and terminates in Lys-NH₂.

Is the peptide amidated?

Yes. The C-terminal Lys is amidated.

Research Use Only.