[D-Pro4,D-Trp7,9,10]-Substance P (4-11) is a classical octapeptide Substance P analog containing D-Pro at position 4 and D-Trp at positions 7, 9 and 10.

The extensive stereochemical and aromatic substitutions convert the C-terminal Substance P fragment into a peptide tachykinin antagonist that has been studied in smooth-muscle, signaling and central nervous system models.

Product Information

A Classical D-Amino-Acid Substance P Antagonist

The analog belongs to an early generation of peptide tachykinin antagonists developed by replacing selected residues within the SP(4-11) pharmacophore with D-amino acids and bulky aromatic side chains.

D-Trp10 replaces the native Leu10 residue, substantially increasing aromatic character in the C-terminal region.

Tissue-Dependent Antagonist Pharmacology

The peptide has inhibited Substance P and other tachykinin responses in multiple smooth-muscle preparations and has also been evaluated in central nervous system models.

Classical studies showed that its apparent antagonist potency varies between tissues. This observation helped establish that early functional preparations could contain different tachykinin receptor populations.

We recommend treating this compound as a classical pharmacological tool rather than assigning a single modern receptor-subtype affinity to all experimental systems.

Research Applications

[D-Pro4,D-Trp7,9,10]-Substance P (4-11) can support tachykinin antagonist studies, smooth-muscle pharmacology, inositol phosphate signaling experiments, CNS Substance P research and peptide SAR.

Frequently Asked Questions

Is this an NK1-selective antagonist?

It is a classical Substance P/tachykinin antagonist, but historical studies show substantial tissue dependence. It should not automatically be treated as equivalent to a modern highly selective NK1 small-molecule antagonist.

What is replaced at position 10?

Native Leu10 is replaced by D-Trp.

Is Met11 retained?

Yes. The C-terminal Met-NH₂ remains present.

Research Use Only.