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Interleukin-6 Receptor Peptide is a 12-residue fragment from the membrane-proximal stalk region of human IL-6R. Its sequence, Thr-Ser-Leu-Pro-Val-Gln-Asp-Ser-Ser-Ser-Val-Pro (TSLPVQDSSSVP), spans a region involved in proteolytic shedding of the membrane-bound receptor.
This defined fragment is particularly useful for research on IL-6 receptor processing, ADAM-family protease recognition and generation of soluble IL-6R.
Product Information
| Property | Specification |
|---|---|
| Product Name | Interleukin-6 Receptor Peptide |
| Catalog No. | AS2696 |
| Sequence | Thr-Ser-Leu-Pro-Val-Gln-Asp-Ser-Ser-Ser-Val-Pro |
| One-Letter Sequence | TSLPVQDSSSVP |
| Peptide Length | 12 amino-acid residues |
| Molecular Formula | C51H85N13O21 |
| Molecular Weight | Approximately 1216.3 Da |
| Protein Context | Human IL-6 receptor stalk region |
| Research Areas | IL-6R shedding, ADAM proteases, soluble IL-6R, cytokine receptor processing |
IL-6R Shedding-Site Sequence
The TSLPVQDSSSVP sequence encompasses the membrane-proximal region of human IL-6R associated with receptor ectodomain shedding.
Mass-spectrometric studies of soluble human IL-6R have localized physiologically relevant proteolysis between Pro355 and Val356. This cleavage region is processed by ADAM17 and is also relevant to ADAM10-dependent receptor shedding.
The serine-rich sequence downstream of the cleavage region contributes to the local physicochemical environment of the receptor stalk and has been investigated in studies of protease recognition.
Why IL-6R Shedding Matters
Proteolytic release of membrane IL-6R generates soluble IL-6R, which can participate in IL-6 trans-signaling through gp130-expressing cells.
This peptide does not reproduce the structure or ligand-binding function of the complete IL-6 receptor. We recommend using it as a defined receptor-stalk fragment for cleavage-site, protease and sequence-recognition studies rather than as a substitute for soluble IL-6R protein.
Research Applications
Applications include ADAM17 substrate-recognition studies, IL-6R shedding research, analysis of membrane-proximal receptor sequences and development of modified cleavage-site peptides.
Researchers working with related cytokine-derived fragments can explore our Immunomodulatory Peptides collection.
Frequently Asked Questions
Does this peptide represent the full IL-6 receptor?
No. It is a short sequence derived from the membrane-proximal stalk region of human IL-6R.
Why is the Pro-Val region important?
Proteomic studies have identified cleavage between Pro355 and Val356 during generation of soluble human IL-6R.
Can altered IL-6R cleavage-site peptides be prepared?
Point mutations, truncations and labeled receptor-derived sequences can be evaluated through Chemical Peptide Synthesis.