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IL-2 (60-70) is an 11-residue fragment of human interleukin-2 with the sequence Leu-Thr-Phe-Lys-Phe-Tyr-Met-Pro-Lys-Lys-Ala (LTFKFYMPKKA).
The peptide provides a chemically defined portion of the IL-2 polypeptide for sequence-focused research, peptide modification studies and experiments that do not require the complete folded cytokine.
Product Information
| Property | Specification |
|---|---|
| Product Name | IL-2 (60-70) Peptide |
| Catalog No. | AS2694 |
| CAS No. | 800379-41-3 |
| Sequence | Leu-Thr-Phe-Lys-Phe-Tyr-Met-Pro-Lys-Lys-Ala |
| One-Letter Sequence | LTFKFYMPKKA |
| Peptide Length | 11 amino-acid residues |
| Molecular Formula | C68H104N14O14S |
| Molecular Weight | Approximately 1373.7 Da |
| Protein Context | Human IL-2 residues 60-70 |
A Defined IL-2 Sequence Fragment
Full-length IL-2 is a folded cytokine whose biological signaling depends on three-dimensional interactions with IL-2 receptor subunits. The isolated 60-70 sequence represents only one local region of that protein.
We therefore recommend describing IL-2 (60-70) as a cytokine-derived peptide fragment rather than assuming that it reproduces the receptor agonism or cellular activity of intact IL-2.
Sequence Features
The fragment contains two phenylalanines, one tyrosine, one methionine and three lysine residues, giving the short sequence both hydrophobic and basic character.
These features can be relevant to peptide solubility, chromatographic retention and modification strategy. Methionine oxidation should also be considered when the peptide is stored or handled for extended periods.
Research Applications
IL-2 (60-70) can support peptide-fragment studies, epitope-oriented research, sequence-specific antibody work and investigation of modified cytokine-derived peptides.
Researchers working with another defined IL-2 region can compare this sequence with IL-2 (44-56) Peptide.
Frequently Asked Questions
Does IL-2 (60-70) have the same activity as full-length IL-2?
It should not be assumed to do so. Full IL-2 signaling depends on the folded cytokine and its interactions with the IL-2 receptor complex.
How many amino acids are in IL-2 (60-70)?
The fragment contains 11 amino-acid residues.
Can labeled or modified IL-2 fragments be synthesized?
Biotinylated, fluorescent and sequence-modified cytokine fragments can be evaluated through Chemical Peptide Synthesis.