$452.00 - $452.00
Human gastrin-releasing peptide (GRP) is a 27-amino-acid C-terminally amidated neuropeptide and an endogenous mammalian ligand of the gastrin-releasing peptide receptor, GRPR/BB2.
GRP belongs to the bombesin-related peptide family and shares important C-terminal sequence features with Bombesin.
Product Information
| Property | Specification |
|---|---|
| Product Name | Gastrin Releasing Peptide, Human |
| Catalog No. | AS2678 |
| CAS No. | 93755-85-2 |
| Sequence | Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH₂ |
| Peptide Length | 27 amino acids |
| Molecular Weight | Approximately 2859.4 Da |
| C-Terminus | Amide |
| Primary Target | GRPR / BB2 |
| Purity | Crude to 98% |
GRPR Pharmacology
Human GRP is useful as a native-sequence ligand for receptor activation, ligand-binding and GRPR-dependent signaling studies.
The C-terminal region contributes strongly to receptor recognition, while the full-length sequence provides the native molecular context absent from shorter bombesin-related ligands.
Experimental Planning
Human GRP can be used in neuroendocrine research, gastrointestinal models and GRPR-expressing cellular systems. We recommend confirming C-terminal amidation, molecular mass and chromatographic purity for quantitative assays.
Our Peptide Quality Control capabilities support batch-specific HPLC and MS documentation.
Frequently Asked Questions
Is human GRP the same molecule as Bombesin?
No. Human GRP is a 27-residue mammalian peptide, whereas Bombesin is a shorter amphibian peptide with a related C-terminal sequence.
Can labeled GRP derivatives be synthesized?
Biotin, fluorescent labels and spacer-containing constructs can be evaluated through Chemical Peptide Synthesis.