H-γ-Glu-Glu-OH; CAS 1116-22-9 is γ-L-glutamyl-L-glutamic acid; gamma-Glu-Glu, a gamma-glutamyl dipeptide in which the peptide bond is formed through the side-chain gamma-carboxyl group of glutamate rather than the conventional alpha-carboxyl group.

That connectivity makes gamma-glutamyl compounds analytically distinct from alpha-linked sequence isomers and relevant to metabolomics, gamma-glutamyl-cycle research and pathway-focused reference work.

Product Information

Gamma-Glutamyl Connectivity and Metabolomics

Gamma-glutamyl dipeptides are distinguished by side-chain amide connectivity at glutamate. They occur in metabolic and food-chemistry contexts and can be measured by LC-MS or related methods. Accurate annotation requires distinguishing gamma-linked species from alpha-linked isomers and confirming retention/mass behavior with an appropriate reference.

Why Gamma Linkage Matters

Gamma-glutamyl and alpha-glutamyl peptides can share residue composition while differing in bond position. Chromatographic or MS/MS methods should therefore be developed with connectivity in mind, especially when assigning biological or food-metabolomics peaks.

Procurement and QC Considerations

For quantitative use, confirm the lot-specific molecular formula, molecular weight and analytical identity against the accompanying COA. Closely related glutamyl compounds should be differentiated by structure as well as nominal mass.

For identity and purity documentation, review our peptide QC methods for HPLC and mass-spectrometric characterization principles.

For broader sequence or project work, see analytical peptide references.

Connectivity and Analytical Assignment

Gamma-linked glutamyl compounds can share residue composition with alpha-linked isomers while differing in bond position. Molecular mass alone is therefore insufficient for connectivity assignment; chromatographic behavior, structural documentation and, when needed, fragmentation data should be considered together.

For quantitative reference use, confirm the lot-specific purity or assay basis and the exact molecular form supplied. This is especially important when closely related positional isomers may be present in the analytical method.

Product Documents

MSDS - H-γ-Glu-Glu-OH (AS4153)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What is H-γ-Glu-Glu-OH?

It is γ-L-glutamyl-L-glutamic acid; gamma-Glu-Glu, a defined research compound with sequence or structural identity γ-Glu-Glu.

Is this an alpha-linked glutamyl peptide?

No. The defining feature is gamma-glutamyl connectivity through the glutamate side-chain carboxyl group.

Why verify connectivity in metabolomics?

Alpha- and gamma-linked isomers can have similar mass but different retention, fragmentation and biological context.

Research Use Only.