H-D-Leu-D-Leu-OMe.HCl is a stereochemically defined peptide methyl ester hydrochloride based on D-Leu-D-Leu. Esterification blocks the C-terminal carboxyl group and the hydrochloride form defines the supplied ionic state.

This makes the compound more appropriate as a synthetic intermediate, stereochemical reference or protected peptide derivative than as a free-acid peptide standard. Identity should be confirmed by sequence, ester state, salt form and lot-specific analytical data.

Product Information

Ester and Salt-State Considerations

The methyl ester masks the free C-terminal carboxyl group, and the hydrochloride counterion changes the supplied ionic form. Those features can alter solubility, chromatography and reactivity. Procurement and analytical records should preserve the ester/salt designation rather than abbreviating the compound to the corresponding free acid.

Why Stereochemical Identity Matters

Short peptides can show large stereochemistry-dependent differences in enzyme recognition and chromatographic behavior. Formula and nominal mass cannot distinguish all stereoisomers, so configuration and salt/ester state should remain explicit in records and sample labels.

Procurement and QC Considerations

Confirm methyl-ester identity, hydrochloride salt form and water/solvent content where relevant. Free acid, ester and salt forms should not be interchanged in quantitative comparisons.

For identity and purity documentation, review our peptide QC methods for HPLC and mass-spectrometric characterization principles.

For broader sequence or project work, see analytical peptide references.

Lot Documentation and Stereochemical Identity

For experiments in which configuration affects enzyme recognition, chromatography or biological stability, the D/L designation should be verified from lot-specific documentation rather than inferred from molecular mass alone. HPLC and MS can support purity and mass identity, but they do not by themselves establish absolute stereochemistry.

If the material will be used quantitatively, review the lot-specific purity basis and preparation concentration. Nominal vial mass should not be interpreted as independently determined net peptide content unless that value is provided in the accompanying analytical documentation.

Product Documents

MSDS - H-D-Leu-D-Leu-OMe.HCl (AS4053)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What is H-D-Leu-D-Leu-OMe.HCl?

It is D-Leu-D-Leu methyl ester hydrochloride, a defined research compound with sequence or structural identity D-Leu-D-Leu-OMe · HCl.

Can another stereoisomer be substituted?

Not when stereochemistry is part of the experiment. Different D/L configurations can share molecular mass but differ in enzyme recognition, packing and chromatography.

Can MS alone confirm stereochemistry?

No. Mass spectrometry can support molecular-mass identity but does not establish absolute configuration by itself.

Research Use Only.