cyclo(His-His) is a cyclic dipeptide composed of two histidine residues closed through the peptide backbone to form a diketopiperazine-type ring. The two imidazole side chains provide the main polar, acid-base and coordination-capable functionality.

Product Information

Cyclic Dipeptide Scaffold

Cyclization removes the free N- and C-termini and creates a compact, conformationally restricted backbone. This changes polarity and geometry relative to linear His-His and can affect imidazole orientation, hydrogen bonding and coordination behavior.

Stereochemical Identity and Analytical Assignment

The molecular formula and nominal mass support cyclic His-His composition but do not establish a specific stereochemical combination. When absolute configuration matters, rely on the structural designation and lot-specific documentation supplied with the material.

LC-MS can support molecular-mass identity and HPLC can assess chromatographic purity, but neither method alone proves absolute stereochemistry. Chiral or structure-specific evidence may be needed for stereochemistry-dependent experiments.

For cyclic sequence projects, see cyclic peptide synthesis.

Product Documents

MSDS - cyclo(His-His) (AS4156)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

Does the molecular mass identify the stereoisomer?

No. Different stereoisomers can share the same molecular formula and mass.

Why are the imidazole groups important?

They can participate in protonation, hydrogen bonding and metal coordination, making orientation and stereochemistry relevant to mechanistic studies.

Research Use Only.