H-D-Phe-L-Phe-OH; CAS 2577-22-2 is the D-phenylalanyl-L-phenylalanine stereoisomer of diphenylalanine. The two phenylalanine side chains create a highly aromatic dipeptide surface, while the residue configuration controls molecular packing and can alter supramolecular behavior.

Diphenylalanine is widely used as a minimal peptide self-assembly motif. For stereochemical comparison, the exact D/L configuration is part of the product identity and should be controlled together with purity and analytical documentation.

Product Information

Aromatic Self-Assembly and Stereochemical Context

Phenylalanine side chains support π-interactions and hydrophobic packing, which is why diphenylalanine is widely used in supramolecular peptide research. Configuration and terminal capping can change packing, morphology and solubility; comparisons should therefore use matched concentration, solvent history and purity.

What Changes with Configuration or Terminal Capping?

Self-assembly is sensitive to molecular geometry, solvent, concentration and sample history. A stereoisomer or N-capped derivative should therefore be treated as a distinct experimental system rather than as an interchangeable version of L-Phe-L-Phe.

Procurement and QC Considerations

For stereochemistry-dependent work, purchase against the exact D/L sequence and request lot-specific analytical documentation. MS alone confirms mass but does not establish absolute configuration.

For identity and purity documentation, review our peptide QC methods for HPLC and mass-spectrometric characterization principles.

For broader sequence or project work, see analytical peptide references.

Lot Documentation and Stereochemical Identity

For experiments in which configuration affects enzyme recognition, chromatography or biological stability, the D/L designation should be verified from lot-specific documentation rather than inferred from molecular mass alone. HPLC and MS can support purity and mass identity, but they do not by themselves establish absolute stereochemistry.

If the material will be used quantitatively, review the lot-specific purity basis and preparation concentration. Nominal vial mass should not be interpreted as independently determined net peptide content unless that value is provided in the accompanying analytical documentation.

Product Documents

MSDS - H-D-Phe-L-Phe-OH (AS4084)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What is H-D-Phe-L-Phe-OH?

It is D-phenylalanyl-L-phenylalanine, a defined research compound with sequence or structural identity D-Phe-L-Phe.

Can another stereoisomer be substituted?

Not when stereochemistry is part of the experiment. Different D/L configurations can share molecular mass but differ in enzyme recognition, packing and chromatography.

Can MS alone confirm stereochemistry?

No. Mass spectrometry can support molecular-mass identity but does not establish absolute configuration by itself.

Research Use Only.