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H-Ala(3-Cl)-OH·HCl is 3-chloro-L-alanine hydrochloride, also described as β-chloro-L-alanine HCl. The molecule contains a chlorine substituent at the β-carbon of the alanine side chain while the amino group is supplied as the hydrochloride salt.
The β-chloro substituent is a synthetic handle rather than a conventional hydrophobic side chain. It can support substitution or transformation chemistry that converts the alanine scaffold into other functionalized amino-acid derivatives.
Product Information
| Product Name | H-Ala(3-Cl)-OH·HCl |
| Chemical Name | 3-Chloro-L-alanine hydrochloride (β-chloro-L-alanine hydrochloride) |
| Catalog No. | AS2101 |
| CAS No. | 51887-89-9 |
| Molecular Formula | C3H7Cl2NO2 |
| Molecular Weight | 160.00 g/mol |
| Compound Type | β-Chloro L-alanine salt |
| Primary Research Use | Electrophilic amino-acid intermediate and precursor to substituted alanine analogs |
β-Chloro Side Chain as a Synthetic Handle
The carbon-chlorine bond at the β-position creates a potentially useful leaving-group site for nucleophilic substitution under appropriate conditions. This makes 3-chloroalanine valuable as a precursor to sulfur-, nitrogen-, oxygen-, or other substituted alanine analogs, depending on the route.
Because elimination and side reactions can compete in strongly basic or forcing conditions, the reaction environment should be selected for the intended substitution and stereochemical outcome.
Salt Form and Stereochemical Identity
The product is supplied as the L-alanine hydrochloride salt. Base equivalents in downstream reactions should account for protonation of the amino group.
For peptide-oriented projects using functionalized residues, related noncanonical amino acids can be compared by side-chain handle and protection state.
When This Material Is Most Useful
H-Ala(3-Cl)-OH·HCl is best viewed as a reactive precursor rather than a ready-to-use standard Fmoc building block. It is particularly relevant when the target residue will be created by replacing the β-chloro group during solution-phase synthesis.
Product Documents
MSDS - H-Ala(3-Cl)-OH·HCl (AS2101)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is another name for H-Ala(3-Cl)-OH·HCl?
3-Chloro-L-alanine hydrochloride and β-chloro-L-alanine hydrochloride are common descriptive names.
Why is the chlorine useful?
The β-chloro group can act as a leaving group in substitution chemistry, enabling synthesis of other side-chain-functionalized alanine derivatives.
Is this an Fmoc-protected amino acid?
No. The amino group is present as an HCl salt; additional protection may be needed for peptide-coupling workflows.