$121.00 - $121.00
gp100 (177–186) is a 10-amino-acid peptide derived from human PMEL/gp100 with the sequence AMLGTHTMEV. It is an HLA-A2-associated melanoma differentiation antigen epitope that has been studied in cytotoxic T-cell responses and peptide-based antigen-presentation systems.
Unlike many catalog epitopes that are considered independently, gp100 (177–186) has a directly overlapping 9-mer counterpart, MLGTHTMEV (178–186). This makes the pair useful for experiments focused on peptide length and N-terminal sequence context.
Product Information
| Property | Specification |
|---|---|
| Product Name | gp100 (177–186) |
| Catalog No. | AS2687 |
| Source Protein | gp100 / PMEL |
| Organism | Human |
| Sequence | AMLGTHTMEV |
| Length | 10 amino acids |
| Molecular Formula | C₄₅H₇₆N₁₂O₁₅S₂ |
| Molecular Weight | 1089.31 Da |
| Reported MHC Context | HLA-A2 / HLA-A*02:01 |
| Peptide Type | Tumor-associated antigen epitope |
| Available Purity | Crude to 98% |
| Form | Lyophilized peptide |
Overlapping Epitope Comparison
The gp100 177–186 decamer differs from the 178–186 nonamer by only the N-terminal alanine. Both sequences have been investigated as HLA-A2-associated gp100 epitopes, providing an experimentally useful comparison without introducing substitutions elsewhere in the sequence.
Researchers studying processing, MHC loading, TCR recognition, or peptide-length effects can compare AS2687 directly with gp100 (178–186), AS2688.
Research Planning
When these peptides are compared in the same experiment, We recommend keeping purity, solvent preparation, peptide concentration, and handling conditions as consistent as possible. This helps reduce analytical variables unrelated to the one-residue sequence difference.
Custom N-terminal extensions, truncations, or residue substitutions can be prepared through Custom Peptide Synthesis when a broader gp100 epitope series is required.
Purity and Documentation
The appropriate specification depends on whether the peptide is being used for preliminary screening, peptide loading, quantitative cellular assays, or another downstream workflow.
Our Recommended Peptide Purity resource provides application-oriented guidance for selecting an appropriate purity range.
Storage and Handling
Store lyophilized gp100 (177–186) under the conditions provided with the supplied batch. After reconstitution, minimize unnecessary temperature cycling and maintain consistent handling when comparing it with related epitopes.
Research Use Only
gp100 (177–186) is supplied for research use only. It is not intended for therapeutic, or human use.